How frozen embryo transfer preparation affects uterine wave activity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort comparing hormone replacement therapy (HRT) protocols versus true or modified natural cycles in patients undergoing frozen embryo transfer. Investigators will measure endometrial peristalsis (uterine wave frequency, amplitude, and pattern) by imaging around the time of transfer and record concurrent hormone levels. The study will correlate peristalsis characteristics with implantation and early pregnancy outcomes without altering participants' planned treatment. Data collection is limited to patients treated at the participating center and follows standard clinical FET procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 - 42 years old
* Scheduled for frozen embryo transfer cycles using hormone replacement therapy protocol or natural cycle protocol (True natural cycles or modified natural cycles)
* Transferred no more than two cleavage embryos or one good-quality blastocyst or no more than two poor-quality blastocysts

Exclusion Criteria:

* Having an allergy and contraindications for exogenous hormone administration (e.g., breast cancer, thromboembolic disease)
* Cycles with preimplantation genetic testing, oocyte donation, or in vitro maturation
* Having untreated uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus, endometrial polyp, large leiomyoma ≥5 cm in diameter, hydrosalpinx, endometrial hyperplasia).
* Use of uterine relaxants or intralipid infusion during the embryo transfer process.
* Use of a GnRH-agonist for downregulation within one month.
* PCOS patients

Where it's running

• My Duc Phu Nhuan Hospital
  Ho Chi Minh City, Vietnam Recruiting
• IVFMD Phu Nhuan - My Duc Phu Nhuan Hospital
  Ho Chi Minh City, Vietnam Not yet recruiting

Study contacts

• Principal investigator: Lan N Vuong, MD, PhD — IVFMD and HOPE Research Center, My Duc Hospital
• Study coordinator: Xuyen Thi Ha Le, MD
• Email: bsxuyen.lth@myduchospital.vn
• Phone: +84945260494

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Endometrial Waves and Pregnancy in FET Cycles with Hormone Therapy

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• Comparing two vaginal progesterone forms for frozen embryo transfer

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  This project will try giving low‑dose levothyroxine to women with subclinical hypothyroidism undergoing IVF/ICSI with frozen embryo transfer to see if it improves pregnancy outcomes.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City, Ho Chi Minh and 1 other locations · NCT07257250

• AI-assisted embryo selection on day 5 in IVF for infertility

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• Unstimulated Egg Retrieval with CAPA-IVM and Euploid Embryo Transfer

  This study tests whether eggs can be collected without ovarian stimulation, matured in the lab, and used to create a single euploid embryo for transfer in infertility patients.

  Recruiting CARE Fertility Texas · Bedford, Texas · NCT07801105

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.