Measuring free radicals in human sperm related to lifestyle and microbiota

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the role of free radicals in male infertility by measuring their levels in sperm cells. Utilizing a novel technique called diamond magnetometry, the study will assess free radical generation in relation to standard semen parameters, lifestyle factors, and microbiota. The research focuses on understanding how oxidative stress from free radicals may contribute to poor semen quality and infertility in men. By identifying these relationships, the study seeks to provide insights into potential diagnostic and therapeutic approaches for male infertility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Males of couples visiting the CRM at the UMCG between 18-55 years old.
* Planned semen-analysis as standard care.

Exclusion Criteria:

* Males who receive(d) chemo- and/or radiotherapy, use(d) testosterone suppletion and/or anabolic steroids
* Males who are azoospermic
* Males who have an abnormal SA due to genetic causes.
* Semen analysis with round cells \>2x106 /ml (as marker for infection)
* Males who currently use antibiotics

Where it's running

• University Medical Centre Groningen
  Groningen, Provincie Groningen, Netherlands Recruiting

Study contacts

• Principal investigator: Astrid EP Cantineau — University Medical Centre Groningen; Centre of Reproductive Medicine
• Study coordinator: Astrid EP Cantineau, Dr.
• Email: a.e.p.cantineau@umcg.nl
• Phone: +31(0)50-3613032

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.