Measuring free radicals in human sperm related to lifestyle and microbiota
MeaSuring Free radIcals With Diamond magnetometrRy In hUman Single Sperm Cells Related to Microbiota and Lifestyle Factors
This study is testing how free radicals in sperm might affect male infertility by looking at their levels in relation to lifestyle and gut bacteria.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | Male |
| Sponsor | University Medical Center Groningen Academic / other |
| Locations | 1 site (Groningen, Provincie Groningen) |
| Trial ID | NCT05514223 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the role of free radicals in male infertility by measuring their levels in sperm cells. Utilizing a novel technique called diamond magnetometry, the study will assess free radical generation in relation to standard semen parameters, lifestyle factors, and microbiota. The research focuses on understanding how oxidative stress from free radicals may contribute to poor semen quality and infertility in men. By identifying these relationships, the study seeks to provide insights into potential diagnostic and therapeutic approaches for male infertility.
Who should consider this trial
Good fit: Ideal candidates for this study are males aged 18-55 who are part of couples seeking fertility evaluation and are scheduled for semen analysis.
Not a fit: Patients who are azoospermic, have genetic causes for abnormal semen analysis, or are currently using antibiotics may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods and treatments for male infertility.
How similar studies have performed: While the approach of measuring free radicals in sperm is novel, preliminary data from related studies in other cell types suggest potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males of couples visiting the CRM at the UMCG between 18-55 years old. * Planned semen-analysis as standard care. Exclusion Criteria: * Males who receive(d) chemo- and/or radiotherapy, use(d) testosterone suppletion and/or anabolic steroids * Males who are azoospermic * Males who have an abnormal SA due to genetic causes. * Semen analysis with round cells \>2x106 /ml (as marker for infection) * Males who currently use antibiotics
Where this trial is running
Groningen, Provincie Groningen
- University Medical Centre Groningen — Groningen, Provincie Groningen, Netherlands (Recruiting)
Study contacts
- Principal investigator: Astrid EP Cantineau — University Medical Centre Groningen; Centre of Reproductive Medicine
- Study coordinator: Astrid EP Cantineau, Dr.
- Email: a.e.p.cantineau@umcg.nl
- Phone: +31(0)50-3613032
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.