A new 3D printed device for delivering progesterone to help with infertility

Innovative 3D Printed Intravaginal Ring AnelleO-PRO, the first Single Administration of Progesterone for Infertility

NIH-funded research Anelleo, INC. · NIH-10932305

This study is testing a new 3D printed ring that releases progesterone over 28 days to help women going through fertility treatments like IVF, making it easier and more convenient for them to get the hormones they need.

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionAnelleo, INC. NIH-funded
Lab location1 site (Chapel Hill, United States)
Project IDNIH-10932305 on NIH RePORTER

What this research studies

This research focuses on developing a 3D printed intravaginal ring called AnelleO-PRO, designed to deliver progesterone over a 28-day period to support women undergoing assisted reproductive technology (ART) like in vitro fertilization (IVF). The device aims to improve patient compliance by providing a more convenient and effective method of hormone delivery compared to traditional options such as gels or injections. By utilizing advanced 3D printing technology, the ring can be produced quickly and cost-effectively, ensuring a steady release of progesterone throughout the critical early stages of pregnancy. This innovative approach addresses the common challenges faced by patients in maintaining adequate hormone levels during ART treatments.

Who could benefit from this research

Good fit: Ideal candidates for this research are women of reproductive age who are experiencing infertility and are undergoing assisted reproductive technology treatments.

Not a fit: Patients who are not seeking fertility treatments or who have contraindications to progesterone therapy may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly improve the chances of pregnancy for women undergoing fertility treatments by providing a more effective and user-friendly method of hormone supplementation.

How similar studies have performed: Previous research has shown promise in using intravaginal rings for hormone delivery, making this approach a potentially successful advancement in fertility treatment.

Where this research is happening

Chapel Hill, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.