Comparing two methods for sperm preparation in IVF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of two sperm preparation methods, microfluidic chip and density gradient centrifugation, in improving the euploidy rate during pre-implantation genetic testing (PGT) for couples undergoing in vitro fertilization (IVF). Infertile women will be recruited and randomly assigned to one of the two groups during their IVF treatment. The study will maintain blinding for both participants and clinicians to ensure unbiased results. The primary goal is to determine which method yields better outcomes in terms of genetic viability of embryos.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged \<43 years at the time of ovarian stimulation for IVF
* Women undergoing PGT for monogenic diseases, structural rearrangement of chromosomes or aneuploidy
* Sperm concentration of the raw semen with at least 0.15 million motile sperm per ml or 100 motile sperm per 50 low power field (200x) of observation

Exclusion Criteria:

* Use of frozen semen for insemination
* Use of donor oocytes and spermatozoa
* Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated;
* Women who had been recruited into this study before and
* Women joining other randomized trials

Where it's running

• Department of Obstetrics and Gynaecology
  Hong Kong, Hong Kong, China Recruiting

Study contacts

• Study coordinator: Yu Wing Tong, Mbbs
• Email: ptong@connect.hku.hk
• Phone: 92707722

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ultra-Long GnRH-a Pretreatment Before Frozen Embryo Transfer for Deep Infiltrating Endometriosis

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.