Investigating the link between AMH levels and embryo ploidy status

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine if there is a correlation between intrafollicular levels of Anti-Müllerian hormone (AMH) and the ploidy status of blastocysts on the day of egg retrieval after ovarian stimulation for intracytoplasmic sperm injection (ICSI). By analyzing hormonal environments surrounding oocytes and utilizing Next Generation Sequencing (NGS) to assess chromosomal pairs, the study seeks to provide insights into embryo quality and implantation potential. Data will be collected and analyzed to enhance embryo selection and optimize ovarian stimulation protocols for better fertility outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At least one follicle from each ovary at day of trigger
* Age from 18 to 40 years old
* Normal menstrual cycle of 25-35 days
* Poor, normal and high response will be included
* First follicle punctured from each ovary will be consider for inclusion: if the COC (Cumulus Oocyte Complex) is present in clear FF (Follicular fluid), the FF will be collected separately for further analysis and the oocyte included in the study

Exclusion Criteria:

* Very hematic follicular fluid
* If the COC is not found in the follicular fluid
* Azoospermia
* Known chromosomal abnormalities
* Severe OAT (Oligoasthenoteratozoospermia)

Where it's running

• ART Fertility Clinics LLC
  Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates Recruiting

Study contacts

• Principal investigator: Laura Melado, PhD — ART Fertility Clinics LLC
• Study coordinator: Barbara Lawrenz, PhD
• Email: barbara.lawrenz@artfertilityclinics.com
• Phone: 0097126528000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.