Outcomes for couples after unsuccessful PGD at the Paris PGD Center
Official title: Outcomes of Couples After Failed PGD Management: A Single-Center Study at the Paris PGD Center (Antoine Béclère - Necker)
Run by Assistance Publique - Hôpitaux de Paris · NCT07371312 · Data updated 2026-11-12
This project will see what happens next for couples who started PGD at the Paris center but did not have a live birth from that care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 900 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Clamart) |
| Status | Recruiting |
| Started | March 25, 2026 |
| Main results expected | March 25, 2028 |
| Study ends | March 25, 2028 |
| Registry record updated | April 21, 2026 |
| Trial ID | NCT07371312 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women who underwent at least one ovarian stimulation cycle for IVF with PGD at the Antoine Béclère center, had no subsequent PGD procedures at the center after December 31, 2022, have no live-born child from PGD there, and who did not object to participation are eligible.
✕Probably not a fit
Patients who had a live-born child from PGD at the center, whose PGD involved gamete donation, or who received PGD care elsewhere or continued PGD at this center after December 31, 2022 are unlikely to benefit from this study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center observational review of women in couples who began at least one ovarian stimulation cycle for IVF with preimplantation genetic diagnosis (PGD) at the Antoine Béclère Paris PGD Center and who had no live birth from that care. Investigators will use clinical records and follow-up information to document reproductive outcomes, decisions made after PGD failure, and related medical histories for cases with no further PGD procedures at the center after December 31, 2022. The study excludes cases involving gamete donation and those with a live-born child resulting from PGD at the center. Results will describe patterns of subsequent care and outcomes among this specific patient group.
Why it matters
Potential benefit: If successful, the findings could give clearer, evidence-based guidance to couples and clinicians about likely reproductive paths and options after unsuccessful PGD.
How similar studies have gone: Similar retrospective and single-center analyses of outcomes after ART/PGT exist but are relatively limited and show variable results depending on population and center practices.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Woman belonging to a couple who initiated at least one ovarian stimulation cycle for IVF (± ICSI) with preimplantation genetic diagnosis (PGD). * No further PGD-related procedures (oocyte retrieval or embryo transfer) performed in the center after December 31, 2022. * No live-born child resulting from PGD care. * Woman who expressed her free and informed non-opposition to participation. Exclusion Criteria: * One or more live-born children resulting from PGD care in the center. * PGD involving gamete donation.
Where it's running
-
Hôpital Antoine Béclère
Clamart, France Recruiting
Study contacts
- Principal investigator: Charlotte SONIGO, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Charlotte SONIGO, PhD
- Email: charlotte.sonigo@aphp.fr
- Phone: 00 33 1 45 37 47 68
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.