Outcomes for couples after unsuccessful PGD at the Paris PGD Center
Outcomes of Couples After Failed PGD Management: A Single-Center Study at the Paris PGD Center (Antoine Béclère - Necker)
This project will see what happens next for couples who started PGD at the Paris center but did not have a live birth from that care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 900 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Clamart) |
| Trial ID | NCT07371312 on ClinicalTrials.gov |
What this trial studies
This is a single-center observational review of women in couples who began at least one ovarian stimulation cycle for IVF with preimplantation genetic diagnosis (PGD) at the Antoine Béclère Paris PGD Center and who had no live birth from that care. Investigators will use clinical records and follow-up information to document reproductive outcomes, decisions made after PGD failure, and related medical histories for cases with no further PGD procedures at the center after December 31, 2022. The study excludes cases involving gamete donation and those with a live-born child resulting from PGD at the center. Results will describe patterns of subsequent care and outcomes among this specific patient group.
Who should consider this trial
Good fit: Women who underwent at least one ovarian stimulation cycle for IVF with PGD at the Antoine Béclère center, had no subsequent PGD procedures at the center after December 31, 2022, have no live-born child from PGD there, and who did not object to participation are eligible.
Not a fit: Patients who had a live-born child from PGD at the center, whose PGD involved gamete donation, or who received PGD care elsewhere or continued PGD at this center after December 31, 2022 are unlikely to benefit from this study's findings.
Why it matters
Potential benefit: If successful, the findings could give clearer, evidence-based guidance to couples and clinicians about likely reproductive paths and options after unsuccessful PGD.
How similar studies have performed: Similar retrospective and single-center analyses of outcomes after ART/PGT exist but are relatively limited and show variable results depending on population and center practices.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Woman belonging to a couple who initiated at least one ovarian stimulation cycle for IVF (± ICSI) with preimplantation genetic diagnosis (PGD). * No further PGD-related procedures (oocyte retrieval or embryo transfer) performed in the center after December 31, 2022. * No live-born child resulting from PGD care. * Woman who expressed her free and informed non-opposition to participation. Exclusion Criteria: * One or more live-born children resulting from PGD care in the center. * PGD involving gamete donation.
Where this trial is running
Clamart
- Hôpital Antoine Béclère — Clamart, France (Recruiting)
Study contacts
- Principal investigator: Charlotte SONIGO, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Charlotte SONIGO, PhD
- Email: charlotte.sonigo@aphp.fr
- Phone: 00 33 1 45 37 47 68
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.