Pentoxifylline to improve uterine lining and frozen embryo transfer outcomes
Effect of Pentoxyfilline on Endometrial Thickness and Frozen Embryo Transfer Outcomes
This trial sees if giving pentoxifylline alongside standard estradiol helps women with good-quality day‑5 frozen embryos get a thicker uterine lining and better frozen embryo transfer success.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 43 Years |
| Sex | Female |
| Sponsor | Beni-Suef University Academic / other |
| Locations | 1 site (Banī Suwayf, Beni Suweif Governorate) |
| Trial ID | NCT07499817 on ClinicalTrials.gov |
What this trial studies
This Phase 3 randomized, parallel study enrolled 100 women aged 18–43 with good-quality day‑5 frozen embryos and unexplained infertility, randomized 1:1 to estradiol alone or estradiol plus pentoxifylline 400 mg daily. Endometrial thickness was measured by transvaginal ultrasound and frozen embryo transfer outcomes (implantation and pregnancy rates) were recorded. Treatment began on cycle day 1 and continued until the day progesterone was started; allocation used computer-generated randomization with sealed opaque envelopes. Patients with endocrine disease, prior surgeries that could compromise the endometrium, or significant cardiovascular, renal, or liver disease were excluded.
Who should consider this trial
Good fit: Women about 18–43 years old with unexplained infertility who have good-quality day‑5 frozen embryos and no endocrine, significant cardiac/renal/hepatic disease or prior endometrial‑compromising surgery.
Not a fit: Patients with known endocrine disorders, significant cardiovascular/renal/hepatic disease, prior surgery that compromised the endometrium, or those not using day‑5 frozen embryos are unlikely to benefit.
Why it matters
Potential benefit: If successful, adding pentoxifylline could increase endometrial thickness and improve implantation and pregnancy rates for women having frozen embryo transfers.
How similar studies have performed: Smaller prior studies of pentoxifylline and other vasodilators for endometrial thickness have reported mixed results, so the approach has some precedent but is not definitively proven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * as good quality day five frozen embryos. Exclusion Criteria: * history of endocrine diseases, * history of any previous surgery that couldm compromise the integrity of endometrium, * cardiovascular, renal and liver diseases,
Where this trial is running
Banī Suwayf, Beni Suweif Governorate
- Beni-suef university Hospital — Banī Suwayf, Beni Suweif Governorate, Egypt (Recruiting)
Study contacts
- Principal investigator: Beni suef University — Beni-Suef University
- Study coordinator: Sara A Salem, MD
- Email: sara.abdalla@med.bsu.edu.eg
- Phone: 01272842226
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.