Pentoxifylline to improve uterine lining and frozen embryo transfer outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3 randomized, parallel study enrolled 100 women aged 18–43 with good-quality day‑5 frozen embryos and unexplained infertility, randomized 1:1 to estradiol alone or estradiol plus pentoxifylline 400 mg daily. Endometrial thickness was measured by transvaginal ultrasound and frozen embryo transfer outcomes (implantation and pregnancy rates) were recorded. Treatment began on cycle day 1 and continued until the day progesterone was started; allocation used computer-generated randomization with sealed opaque envelopes. Patients with endocrine disease, prior surgeries that could compromise the endometrium, or significant cardiovascular, renal, or liver disease were excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* as good quality day five frozen embryos.

Exclusion Criteria:

* history of endocrine diseases,
* history of any previous surgery that couldm compromise the integrity of endometrium,
* cardiovascular, renal and liver diseases,

Where it's running

• Beni-suef university Hospital
  Banī Suwayf, Beni Suweif Governorate, Egypt Recruiting

Study contacts

• Principal investigator: Beni suef University — Beni-Suef University
• Study coordinator: Sara A Salem, MD
• Email: sara.abdalla@med.bsu.edu.eg
• Phone: 01272842226

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.