Investigating outcomes of transferring mosaic embryos in infertility treatment
Official title: A Prospective Study of a Mosaic Embryo Transfer
Run by Colorado Center for Reproductive Medicine · NCT04472156 · Data updated 2026-11-12
This study is trying to see if transferring mosaic embryos, which have both normal and abnormal cells, can help women aged 18-45 who are undergoing IVF have successful pregnancies and live births.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 250 (estimated) |
| Sponsor | Colorado Center for Reproductive Medicine Academic / other |
| Locations | 1 site (Lone Tree, Colorado) |
| Status | Recruiting |
| Started | October 15, 2020 |
| Main results expected | June 15, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | February 29, 2024 |
| Trial ID | NCT04472156 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are infertile women aged 18-45 who have completed an IVF cycle with PGT and have a mosaic embryo available for transfer.
✕Probably not a fit
Patients who do not meet the clinical requirements for embryo transfer or those desiring more than a single embryo transfer may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research investigates the clinical outcomes of transferring mosaic embryos, which contain both normal and abnormal cells, that have been screened using preimplantation genetic testing (PGT). The study involves women aged 18-45 who have undergone an IVF cycle at the Colorado Center for Reproductive Medicine and have a mosaic embryo available for transfer. The aim is to evaluate implantation and live birth rates to determine if these embryos should be routinely offered for transfer, despite current practices that typically exclude them. The study seeks to enhance understanding of the relationship between embryonic mosaicism and successful pregnancies.
Why it matters
Potential benefit: If successful, this study could provide new options for infertile patients by demonstrating that mosaic embryos can lead to healthy pregnancies.
How similar studies have gone: Previous studies have shown that mosaic embryos can result in healthy live births, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women age 18-45 Infertile women who have completed an IVF cycle with PGT at the Colorado Center for Reproductive Medicine (CCRM) that have a mosaic embryo * Patients can be of any race, culture, sexual orientation or ethnicity * Patients that are willing to transfer a single embryo Exclusion Criteria: * Patients that do not meet the clinical requirements for an embryo transfer per clinic standards. * Patients that desire more than a single embryo transfer. * Patients that are using a gestational carrier. * Embryonic mosaic PGT results that include chromosome errors 13, 18, 21 * Patients that did not complete their IVF with PGT cycle at the Colorado Center for Reproductive Medicine.
Where it's running
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Colorado Center for Reproductive Medicine
Lone Tree, Colorado, United States Recruiting
Study contacts
- Principal investigator: Mandy Katz-Jaffe, PhD — Fertility Genetics
- Study coordinator: Rachel Makloski, RN
- Email: rmakloski@colocrm.com
- Phone: 303-788-8300
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Ultra-Long GnRH-a Pretreatment Before Frozen Embryo Transfer for Deep Infiltrating Endometriosis
In people under 40 with deep infiltrating endometriosis and infertility, the study tests whether two injections of a GnRH agonist before hormone support improve pregnancy outcomes in their first frozen-thawed embryo transfer.
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Endometrial Waves and Pregnancy in FET Cycles with Hormone Therapy
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.