Automated freezing of eggs and embryos
Automation of Oocyte and Embryo Vitrification: a Pilot Study
This study will test whether a new automated system called PRESERVE-CR can freeze eggs and embryos as effectively as manual vitrification by embryologists for people having IVF/ICSI.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 125 (estimated) |
| Ages | 18 Years to 38 Years |
| Sex | All |
| Sponsor | Conceivable Life Sciences Industry-sponsored |
| Locations | 1 site (Manchester) |
| Trial ID | NCT07197983 on ClinicalTrials.gov |
What this trial studies
The trial directly compares a prototype automated vitrification device (PRESERVE-CR) with the clinic's standard manual vitrification performed by experienced embryologists. People undergoing IVF/ICSI at CARE Fertility Manchester who consent will have some eggs or embryos frozen using either the automated system or the manual method. The study will measure preservation outcomes such as survival and quality after warming, along with procedure time and operator variability. Results will show whether automation can match manual performance while providing more standardized and efficient workflows.
Who should consider this trial
Good fit: Ideal participants are people undergoing IVF/ICSI at CARE Fertility Manchester with BMI 20–35 kg/m² and AMH ≥1.5 ng/mL who do not require surgical sperm retrieval.
Not a fit: People with low ovarian reserve, those requiring surgical sperm retrieval, or those treated outside the trial criteria or site are unlikely to receive benefit from this study.
Why it matters
Potential benefit: If successful, the automated system could standardize freezing outcomes, reduce training and staffing burdens, lower costs, and help make fertility preservation more accessible.
How similar studies have performed: Automated vitrification approaches are relatively novel with limited published clinical comparison data, while manual vitrification by experienced embryologists remains the established standard.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI: Between 20-35 kg/m² * Ovarian Reserve: Anti-Müllerian Hormone (AMH) ≥1.5 ng/mL Exclusion Criteria: * Low ovarian reserve * Surgical sperm retrieval required
Where this trial is running
Manchester
- CARE Fertility — Manchester, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Giuseppe Silvestri, PhD
- Email: giuseppe@conceivable.life
- Phone: +44 7990960731
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.