Understanding the genetic causes of infertility in humans
Official title: Project 2 - Deciphering the Molecular Drivers of Common Forms of Human Infertility Using Integrative Genomic, Cellular, and Phenomic Approaches
Funded at Massachusetts General Hospital · NIH-11124180 · Data updated 2026-11-12
This study is looking at how our genes might play a role in infertility, helping couples who are trying to have a baby by finding out more about the genetic factors that could be affecting them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 10, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $240,304 |
| NIH project number | 5P50HD104224-05 |
| Project ID | NIH-11124180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals or couples experiencing infertility or those with a family history of reproductive issues.
✕Less likely to help
Patients who are not experiencing infertility or do not have a genetic predisposition to reproductive issues may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to infertility, which affects many couples trying to conceive. By analyzing data from over 18 million individuals, the project aims to identify specific genetic variants linked to both male and female infertility, as well as related reproductive traits. The study employs advanced computational methods to explore the genes and biological pathways involved, ultimately seeking to uncover the root causes of infertility and improve treatment options for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to targeted treatments that address the underlying causes of infertility, improving the chances of conception for many couples.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to infertility, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Lindgren, Cecilia M. — Massachusetts General Hospital
- Study coordinator: Lindgren, Cecilia M.
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This grant aims to uncover the genetic causes of male infertility (azoospermia) to improve diagnosis and pave the way for personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.