Understanding the genetics behind male infertility
Genetics of Male Infertility: Accelerating the pace of discovery
This study is looking at the genes that might cause male infertility, especially a condition called nonobstructive azoospermia, which affects about 1 in 100 men, to help create better tests and treatments for couples dealing with infertility.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project ID | NIH-10992989 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to male infertility, specifically focusing on a condition called nonobstructive azoospermia, which affects about 1% of men. By analyzing genetic variants in affected individuals, the research aims to develop diagnostic tools and personalized treatment options. The project also includes creating advanced laboratory techniques to validate these genetic findings and assess their impact on reproductive health. Ultimately, the goal is to improve counseling for couples facing infertility and enhance treatment strategies based on genetic insights.
Who could benefit from this research
Good fit: Ideal candidates for this research are men aged 20 to 50 who are diagnosed with nonobstructive azoospermia and are seeking answers regarding their infertility.
Not a fit: Patients who do not have male infertility or those with obstructive azoospermia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective diagnostic and treatment options for men experiencing infertility.
How similar studies have performed: Previous research has shown promise in understanding genetic causes of infertility, making this approach a continuation of successful efforts in the field.
Where this research is happening
Pittsburgh, UNITED STATES
- Magee-Women's Res Inst and Foundation — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Orwig, Kyle Edwin — Magee-Women's Res Inst and Foundation
- Study coordinator: Orwig, Kyle Edwin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.