Comparing Day 5 and Day 6 Embryo Transfers for Pregnancy Rates
Impact of a Predetermined Day 5 Embryo Transfer Versus a Predetermined Day 6 Embryo Transfer on the Clinical Pregnancy Rate After Intracytoplasmic Sperm Injection (ICSI) Treatment
Infertility Treatment Center Dortmund · NCT06447077
This study is testing whether transferring embryos on day 5 or day 6 after treatment can lead to higher pregnancy rates for people undergoing fertility treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2400 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Infertility Treatment Center Dortmund (other) |
| Locations | 1 site (Dortmund, North Rhine-Westphalia) |
| Trial ID | NCT06447077 on ClinicalTrials.gov |
What this trial studies
This prospective multicenter study aims to compare the clinical pregnancy rates of predetermined embryo transfers on day 5 versus day 6 after ICSI treatment. The study will involve patients undergoing single embryo transfers at three fertility centers in Germany. The primary endpoint is the detection of a gestational sac per embryo transfer, while the secondary endpoint focuses on the abortion rate per clinical pregnancy. This research seeks to determine if a day 6 transfer could provide advantages in embryo development assessment.
Who should consider this trial
Good fit: Ideal candidates are women aged 18 and older undergoing their first ICSI cycle with a single embryo transfer.
Not a fit: Patients who are not undergoing ICSI treatment or those requiring multiple embryo transfers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could optimize embryo transfer timing, potentially increasing pregnancy rates for patients undergoing ICSI treatment.
How similar studies have performed: While previous studies have compared day 4 and day 5 transfers, this is the first prospective study examining the equivalence of day 5 versus day 6 transfers.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: The patients to be included should be ≥18 years old. There is no upper age limit. Only ICSI treatments with a single embryo transfer (SET) should be included. Only the first cycle per patient should be evaluated. Exclusion criteria: none
Where this trial is running
Dortmund, North Rhine-Westphalia
- Infertility treatment center Dortmund — Dortmund, North Rhine-Westphalia, Germany (RECRUITING)
Study contacts
- Principal investigator: Stefan Dieterle, MD — University of Witten/Herdecke
- Study coordinator: Stefan Dieterle, MD
- Email: dieterle@kinderwunschzentrum.org
- Phone: 00492315575450
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Infertility, Reproductive Issues, ICSI, Predetermined Day 6 Embryo Transfer, Predetermined Day 5 Embryo Transfer