In vitro maturation of human eggs for fertility treatment
In Vitro Maturation of Human Eggs
NA · Colorado Center for Reproductive Medicine · NCT06633120
This study is testing a new way to help women with fertility issues by maturing their eggs in the lab with fewer hormones to see if it makes treatment easier and safer.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | N/A to 38 Years |
| Sex | Female |
| Sponsor | Colorado Center for Reproductive Medicine (other) |
| Locations | 1 site (Lone Tree, Colorado) |
| Trial ID | NCT06633120 on ClinicalTrials.gov |
What this trial studies
This study focuses on in vitro maturation (IVM) of human eggs as a less hormone-intensive alternative to traditional IVF, aiming to make fertility treatment more accessible and reduce side effects. Participants will undergo a complete IVF workup, followed by a low-dose stimulation protocol and egg retrieval. The immature oocytes will be matured in the lab, fertilized, and cultured to the blastocyst stage, with options for genetic testing and embryo transfer included. The study offers a comprehensive package for eligible participants, including consultations and medications.
Who should consider this trial
Good fit: Ideal candidates are infertile women diagnosed with PCOS or polycystic ovaries, with good ovarian reserve and specific hormonal and physical criteria.
Not a fit: Patients who have experienced more than two failed IVF cycles may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a more affordable and less invasive option for women facing infertility, particularly those with PCOS.
How similar studies have performed: Other studies have shown promise with IVM approaches, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Infertile women diagnosed with PCOS or polycystic ovaries, or infertile women with good ovarian reserve * Antral follicle count (AFC) greater than 24 * AMH greater than 3.5 ng/ml * Body Mass Index less than 35 * Accept to have embryos biopsied for PGT * Intend to perform embryo transfer within 4 months after completing the IVM cycle * Paternal (or donor) age \<45, ejaculated sperm collection only (partner frozen and donor sperm acceptable), sperm morphology (strict criteria) \>1%, motility \> 20% and sperm count \> 10 million per ml (so samples can be prepared through standard procedure) Exclusion Criteria: * More than 2 failed IVF cycles
Where this trial is running
Lone Tree, Colorado
- Colorado Center for Reproductive Medicine — Lone Tree, Colorado, United States (RECRUITING)
Study contacts
- Study coordinator: Elizabeth A Jannaman, BS
- Email: EJannaman@CCRMIVF.com
- Phone: 303-788-8300
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy, PCOS, Ovarian Reserve, Infertility, Infertility Female, Infertility of Tubal Origin, Infertility Poly Cystic Ovary, AMH