In vitro maturation of human eggs for fertility treatment
Official title: In Vitro Maturation of Human Eggs
Run by Colorado Center for Reproductive Medicine · NCT06633120 · Data updated 2026-11-12
This study is testing a new way to help women with fertility issues by maturing their eggs in the lab with fewer hormones to see if it makes treatment easier and safer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | Any age to 38 Years |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | Colorado Center for Reproductive Medicine Academic / other |
| Locations | 1 site (Lone Tree, Colorado) |
| Status | Recruiting |
| Started | February 3, 2023 |
| Main results expected | July 31, 2029 |
| Study ends | August 30, 2030 |
| Registry record updated | October 9, 2024 |
| Trial ID | NCT06633120 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are infertile women diagnosed with PCOS or polycystic ovaries, with good ovarian reserve and specific hormonal and physical criteria.
✕Probably not a fit
Patients who have experienced more than two failed IVF cycles may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on in vitro maturation (IVM) of human eggs as a less hormone-intensive alternative to traditional IVF, aiming to make fertility treatment more accessible and reduce side effects. Participants will undergo a complete IVF workup, followed by a low-dose stimulation protocol and egg retrieval. The immature oocytes will be matured in the lab, fertilized, and cultured to the blastocyst stage, with options for genetic testing and embryo transfer included. The study offers a comprehensive package for eligible participants, including consultations and medications.
Why it matters
Potential benefit: If successful, this approach could provide a more affordable and less invasive option for women facing infertility, particularly those with PCOS.
How similar studies have gone: Other studies have shown promise with IVM approaches, indicating potential for success in this area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Infertile women diagnosed with PCOS or polycystic ovaries, or infertile women with good ovarian reserve * Antral follicle count (AFC) greater than 24 * AMH greater than 3.5 ng/ml * Body Mass Index less than 35 * Accept to have embryos biopsied for PGT * Intend to perform embryo transfer within 4 months after completing the IVM cycle * Paternal (or donor) age \<45, ejaculated sperm collection only (partner frozen and donor sperm acceptable), sperm morphology (strict criteria) \>1%, motility \> 20% and sperm count \> 10 million per ml (so samples can be prepared through standard procedure) Exclusion Criteria: * More than 2 failed IVF cycles
Where it's running
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Colorado Center for Reproductive Medicine
Lone Tree, Colorado, United States Recruiting
Study contacts
- Study coordinator: Elizabeth A Jannaman, BS
- Email: EJannaman@CCRMIVF.com
- Phone: 303-788-8300
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.