Identifying new genes linked to male infertility
Official title: Search for new genes involved in male infertility through novel approaches
Funded at Baylor College of Medicine · NIH-10983775 · Data updated 2026-11-12
This study is looking at the DNA of men who have trouble fathering children to find out if there are specific genes or changes in their genes that might be causing infertility, and it hopes to help improve how we diagnose these issues in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 22, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $543,646 |
| NIH project number | 5R01HD106056-04 |
| Project ID | NIH-10983775 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men experiencing unexplained infertility.
✕Less likely to help
Patients with infertility due to known causes or conditions unrelated to genetic factors may not benefit from this research.
What this research studies
This research investigates the genetic causes of male infertility by analyzing the DNA of infertile men and comparing it to that of fertile controls. Using advanced long-read sequencing technology, the study aims to uncover new genes and mutations that may affect male fertility. The findings will be validated through experiments on mouse models to understand the functional implications of these genetic variations. This approach seeks to improve diagnostic capabilities for male infertility beyond current limitations.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and potential treatments for male infertility.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to infertility, but this approach using long-read sequencing is relatively novel.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Garcia, Thomas — Baylor College of Medicine
- Study coordinator: Garcia, Thomas
Related research
Other NIH-funded projects on the same topics.
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This study looks at how heat affects sperm production in males, using tiny worms to understand why higher temperatures might lead to infertility and possibly increase cancer risk, helping us learn more about male reproductive health.
-
Finding genes behind male infertility
This project uses long-read DNA sequencing to find genes and mutations that may cause infertility in men.
-
Genetic causes of male infertility and azoospermia
This project aims to find gene changes that cause nonobstructive azoospermia in men to improve diagnosis and guide future treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.