Clinical trial Recruiting at 1 site Interventional Ages 18 to 89

Selecting sperm for gender-specific offspring

Official title: Sex Selection of Human Spermatozoa

Run by Weill Medical College of Cornell University · NCT05500573 · Data updated 2026-11-12

This study is testing a new way to choose sperm based on whether it carries an X or Y chromosome to help couples undergoing infertility treatment have a baby of a specific gender.

Quick facts

Study typeInterventional
Ages18 Years to 89 Years
SexAll
Enrollment2000 (estimated)
SponsorWeill Medical College of Cornell University
Academic / other
Locations1 site (New York, New York)
StatusRecruiting
StartedNovember 6, 2013
Main results expectedDecember 31, 2028
Study endsDecember 31, 2029
Registry record updatedMay 29, 2026
Trial IDNCT05500573 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are couples undergoing infertility treatment who wish to select the gender of their child for medical or non-medical reasons.

Probably not a fit

Patients with severe male factor infertility may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a reliable and cost-effective method for selecting sperm based on gender. Couples undergoing infertility treatment will provide sperm samples, which will be analyzed using a multilayer density gradient technique to separate X-bearing and Y-bearing spermatozoa. The selected sperm will then be used in standard assisted reproductive procedures such as in vitro fertilization or intrauterine insemination. The effectiveness of the sperm selection will be assessed through FISH analysis to determine the ratio of X- to Y-chromosome bearing sperm.

Why it matters

Potential benefit: If successful, this method could allow couples to have greater control over the gender of their offspring during infertility treatments.

How similar studies have gone: Other studies have explored sperm sorting techniques, but this specific approach using a multilayer density gradient is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Couples undergoing infertility treatment with IVF or insemination seeking gender specific offspring for medical and non medical reasons

Exclusion Criteria:

* Severe male factor

Where it's running

  • Center for Reproductive Medicine- Weill Cornell Medicine
    New York, New York, United States
    Recruiting

Study contacts

  • Principal investigator: Gianpiero Palermo, MD, PhD — Weill Medical College of Cornell University
  • Study coordinator: Rodriq Stubbs, MS, NP
  • Email: res2011@med.cornell.edu
  • Phone: 646-962-3276

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.