Selecting sperm for gender-specific offspring
Sex Selection of Human Spermatozoa
NA · Weill Medical College of Cornell University · NCT05500573
This study is testing a new way to choose sperm based on whether it carries an X or Y chromosome to help couples undergoing infertility treatment have a baby of a specific gender.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 2000 (estimated) |
| Ages | 18 Years to 89 Years |
| Sex | All |
| Sponsor | Weill Medical College of Cornell University (other) |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05500573 on ClinicalTrials.gov |
What this trial studies
This study aims to develop a reliable and cost-effective method for selecting sperm based on gender. Couples undergoing infertility treatment will provide sperm samples, which will be analyzed using a multilayer density gradient technique to separate X-bearing and Y-bearing spermatozoa. The selected sperm will then be used in standard assisted reproductive procedures such as in vitro fertilization or intrauterine insemination. The effectiveness of the sperm selection will be assessed through FISH analysis to determine the ratio of X- to Y-chromosome bearing sperm.
Who should consider this trial
Good fit: Ideal candidates for this study are couples undergoing infertility treatment who wish to select the gender of their child for medical or non-medical reasons.
Not a fit: Patients with severe male factor infertility may not benefit from this study.
Why it matters
Potential benefit: If successful, this method could allow couples to have greater control over the gender of their offspring during infertility treatments.
How similar studies have performed: Other studies have explored sperm sorting techniques, but this specific approach using a multilayer density gradient is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Couples undergoing infertility treatment with IVF or insemination seeking gender specific offspring for medical and non medical reasons Exclusion Criteria: * Severe male factor
Where this trial is running
New York, New York
- Center for Reproductive Medicine- Weill Cornell Medicine — New York, New York, United States (RECRUITING)
Study contacts
- Principal investigator: Gianpiero Palermo, MD, PhD — Weill Medical College of Cornell University
- Study coordinator: Rodriq Stubbs, MS, NP
- Email: res2011@med.cornell.edu
- Phone: 646-962-3276
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Infertility, IVF