Selecting sperm for gender-specific offspring
Official title: Sex Selection of Human Spermatozoa
Run by Weill Medical College of Cornell University · NCT05500573 · Data updated 2026-11-12
This study is testing a new way to choose sperm based on whether it carries an X or Y chromosome to help couples undergoing infertility treatment have a baby of a specific gender.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 89 Years |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | November 6, 2013 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2029 |
| Registry record updated | May 29, 2026 |
| Trial ID | NCT05500573 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are couples undergoing infertility treatment who wish to select the gender of their child for medical or non-medical reasons.
✕Probably not a fit
Patients with severe male factor infertility may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to develop a reliable and cost-effective method for selecting sperm based on gender. Couples undergoing infertility treatment will provide sperm samples, which will be analyzed using a multilayer density gradient technique to separate X-bearing and Y-bearing spermatozoa. The selected sperm will then be used in standard assisted reproductive procedures such as in vitro fertilization or intrauterine insemination. The effectiveness of the sperm selection will be assessed through FISH analysis to determine the ratio of X- to Y-chromosome bearing sperm.
Why it matters
Potential benefit: If successful, this method could allow couples to have greater control over the gender of their offspring during infertility treatments.
How similar studies have gone: Other studies have explored sperm sorting techniques, but this specific approach using a multilayer density gradient is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Couples undergoing infertility treatment with IVF or insemination seeking gender specific offspring for medical and non medical reasons Exclusion Criteria: * Severe male factor
Where it's running
-
Center for Reproductive Medicine- Weill Cornell Medicine
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Gianpiero Palermo, MD, PhD — Weill Medical College of Cornell University
- Study coordinator: Rodriq Stubbs, MS, NP
- Email: res2011@med.cornell.edu
- Phone: 646-962-3276
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.