Comparing two methods for sperm preparation in IVF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to compare the effectiveness of a microfluidic chip method against a density-gradient centrifugation method for sperm preparation in infertile patients undergoing in-vitro fertilization (IVF). Infertile women under 43 years old will be randomly assigned to one of the two groups during ovarian stimulation for IVF at Queen Mary Hospital and Kwong Wah Hospital. The primary outcome measured will be the cumulative live birth rate within six months of randomization, with both patients and clinicians blinded to group allocation. The study seeks to determine if the microfluidic chip can improve live birth rates compared to the traditional method.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Infertile women aged \<43 years at the time of ovarian stimulation for IVF

Exclusion Criteria:

* Women undergoing preimplantation genetic testing monogenic diseases, structural rearrangement of chromosomes or aneuploidy;
* Male factor requiring surgical sperm retrieval such as microscopic epididymal sperm aspiration and testicular sperm extraction;
* Use of donor oocytes and spermatozoa;
* Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated;
* Women who had been recruited into this study before and
* Women joining other randomized trials

Where it's running

• Department of Obstetrics and Gynaecology
  Hong Kong, Hong Kong, China Recruiting

Study contacts

• Study coordinator: Yu Wing Tong, Mbbs
• Email: ptong@connect.hku.hk
• Phone: 92707722

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.