Fertility outcomes after antibiotic treatment in women with chronic endometritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective cohort study will estimate how common chronic endometritis is among women undergoing infertility evaluation and see if antibiotic treatment improves reproductive outcomes. It will compare hysteroscopic findings with lab confirmation of CE and explore the uterine bacterial landscape to understand potential links to fertility and pregnancy. Histology and CD138 staining will confirm CE, while documented hysteroscopic markers will be evaluated for diagnostic value. Participants are women aged 18-40 undergoing diagnostic hysteroscopy with endometrial biopsy, diagnosed with CE, and willing to receive antibiotic treatment and follow their reproductive outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Female participants aged 18-40 years.
* Diagnosis of infertility (primary or secondary infertility).
* Indication for diagnostic hysteroscopy with endometrial biopsy as part of infertility evaluation.
* Suspected or confirmed chronic endometritis.
* Ability and willingness to provide written informed consent prior to any study-related procedures.
* Willingness to undergo protocol-defined antibiotic treatment.
* Willingness to comply with study procedures and follow-up assessments.
* Agreement to reproductive outcome monitoring following treatment, including spontaneous conception and pregnancies achieved through assisted reproductive technologies (ART).

Exclusion Criteria

* Age \>40 years.
* Current pregnancy.
* Known hypersensitivity or contraindication to tetracycline antibiotics or other study-related antibiotic therapy without a suitable alternative treatment option.
* Severe systemic disease or medical condition that, in the opinion of the investigator, could interfere with study participation, safety, or interpretation of study results.
* Active malignant disease requiring systemic treatment.
* HIV infection or other severe immunodeficiency disorder.
* Acute pelvic inflammatory disease or clinically significant active genital tract infection requiring immediate treatment.
* Previous participation in this study.
* Inability to undergo planned hysteroscopy or endometrial biopsy.
* Inability or unwillingness to comply with study procedures or follow-up requirements.
* Failure or refusal to provide written informed consent.

Where it's running

• Faculty Hospital Královské Vinohrady
  Prague, Czechia Recruiting
• PRONATAL Sanatorium
  Prague, Czechia Recruiting

Study contacts

• Principal investigator: Borek Sehnal, MD,PhD. — Faculty Hospital Královské Vinohrady, Prague
• Study coordinator: Krystof Brecka, MD
• Email: krystof.brecka@fnkv.cz
• Phone: 0042060417263

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.