Endometrial Waves and Pregnancy in FET Cycles with Hormone Therapy
Official title: Correlation Between Endometrial Peristalsis And Pregnancy Outcomes In Patients Undergoing Frozen Embryo Transfer With Hormone Replacement Therapy for Endometrial Preparation Protocol
Run by Mỹ Đức Hospital · NCT07675213 · Data updated 2026-11-12
This study tests whether patterns of uterine contractions during hormone-prepared frozen embryo transfer affect pregnancy outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 42 Years |
| Sex | Women only |
| Enrollment | 442 (estimated) |
| Sponsor | Mỹ Đức Hospital Academic / other |
| Locations | 1 site (Ho Chi Minh City) |
| Status | Recruiting |
| Started | June 30, 2026 |
| Main results expected | June 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | July 9, 2026 |
| Trial ID | NCT07675213 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women 18–42 years old planning a hormone replacement therapy–prepared FET and meeting embryo transfer criteria.
✕Probably not a fit
Patients with non-responding endometrium or cycles not meeting ultrasound assessment time points may not see a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study will measure endometrial peristalsis using transvaginal ultrasound at predefined times during hormone replacement therapy–prepared FET cycles. It aims to see if the frequency or direction of uterine contractions relates to implantation and pregnancy success. Eligible participants are women aged 18–42 undergoing FET with HRT and meeting certain embryo transfer criteria. Data on hormone levels and peristaltic patterns will be analyzed to identify possible associations with outcomes. The goal is to clarify whether endometrial activity should be considered in ART planning.
Why it matters
Potential benefit: If associations are found, clinicians may tailor endometrial assessment or timing to improve pregnancy chances in FET cycles.
How similar studies have gone: Prior research suggests endometrial contractions influence implantation in natural cycles; evidence in HRT-prepared FET is limited and this study explores that gap.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 18 - 42 years old * Scheduled for frozen embryo transfer cycles using hormone replacement therapy protocol * Transferred no more than two cleavage embryos or one good-quality blastocyst or no more than two poor-quality blastocysts * Provision of written informed consent to participate Exclusion Criteria: * Having an allergy and contraindications for exogenous hormone administration (e.g., breast cancer, thromboembolic disease) * Cycles with preimplantation genetic testing, oocyte donation, or in vitro maturation * Having untreated uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus, endometrial polyp, large leiomyoma ≥5 cm in diameter, hydrosalpinx, endometrial hyperplasia) * Use of uterine relaxants or intralipid infusion during the embryo transfer process * Use of a GnRH-agonist for downregulation within one month
Where it's running
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IVFMD - My Duc Hospital
Ho Chi Minh City, Vietnam Recruiting
Study contacts
- Principal investigator: Lan N Vuong, MD, PhD — University of Medicine and Pharmacy at Ho Chi Minh City
- Study coordinator: Nhi NL Ho, MD
- Email: drnhiho@gmail.com
- Phone: +84903497611
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How frozen embryo transfer preparation affects uterine wave activity
We will test whether preparing for frozen embryo transfer with hormones or using a natural cycle changes uterine contractions in women having FET.
-
Comparing two vaginal progesterone forms for frozen embryo transfer
This compares whether soft vaginal progesterone capsules are easier to use, better tolerated, and give similar pregnancy results as vaginal progesterone pessaries for women having frozen embryo transfer.
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Levothyroxine for women with mild (subclinical) hypothyroidism having IVF/ICSI and frozen embryo transfer
This project will try giving low‑dose levothyroxine to women with subclinical hypothyroidism undergoing IVF/ICSI with frozen embryo transfer to see if it improves pregnancy outcomes.
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AI-assisted embryo selection on day 5 in IVF for infertility
This trial tests whether an AI-based embryo selection tool can help pick the best embryo for transfer on day 5 in IVF/ICSI to improve pregnancy chances for people with infertility.
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Preserving sperm quality with aging through cryopreservation
This study tests whether freezing and thawing sperm can help keep younger-like DNA and molecular traits in men as they age.
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Unstimulated Egg Retrieval with CAPA-IVM and Euploid Embryo Transfer
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.