AI-assisted embryo selection on day 5 in IVF for infertility
Official title: Evaluation of the Use of Artificial Intelligence (AiVF) in Embryo Selection in Assisted Reproduction for Embryos Cultured to the Fifth Day of Development
Run by University Hospital, Clermont-Ferrand · NCT07844083 · Data updated 2026-11-12
This trial tests whether an AI-based embryo selection tool can help pick the best embryo for transfer on day 5 in IVF/ICSI to improve pregnancy chances for people with infertility.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 37 Years |
| Sex | Women only |
| Enrollment | 550 (estimated) |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand) |
| Status | Recruiting |
| Started | November 4, 2024 |
| Main results expected | November 1, 2026 |
| Study ends | November 1, 2027 |
| Registry record updated | September 28, 2026 |
| Trial ID | NCT07844083 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Individuals/couples undergoing their first IVF/ICSI cycle for primary infertility, using fresh partner or donor sperm, with embryos cultured to day 5 and a first fresh transfer planned.
✕Probably not a fit
Patients not achieving a clinical pregnancy by the assessment point or whose embryos are not cultured to day 5 may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study uses EMA, an AI software, to guide which embryo to transfer after culture to day 5. Eligible participants are individuals or couples undergoing their first IVF/ICSI cycle for primary infertility (idiopathic or male-factor) using fresh sperm. Embryos are cultured to the fifth day and scored by the AI system to help decide which single embryo to transfer, with clinical pregnancy confirmed by heartbeat at 6 weeks as the implantation data. The objective is to see if AI-assisted selection can improve live birth outcomes while reducing the need for multiple embryo transfers. The study takes place at CHU de Clermont-Ferrand under a lead sponsor from University Hospital, Clermont-Ferrand.
Why it matters
Potential benefit: If successful, AI-assisted selection could increase pregnancy rates and reduce multiple pregnancies by guiding single-embryo transfers.
How similar studies have gone: Prior use of time-lapse and embryo selection algorithms in ART has shown potential improvements, but results vary; this trial tests AI EMA specifically for day-5 single-embryo transfer.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * First attempt at assisted reproductive technology (ART) treatment using in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) * Treatment for primary infertility of idiopathic or male origin, for single women or female couples * Use of fresh sperm from the partner or frozen donor sperm * Embryo culture up to the 105th hour of development (the time at which the score is assigned when selecting the embryo to be transferred to the uterus on the 5th day of development (D5)) * First transfer of a fresh embryo on the 5th day of culture * Known Implantation Data (KID) (= clinical pregnancy confirmed by the presence of a heartbeat at 6 weeks via ultrasound) Exclusion Criteria: * Use of frozen sperm from the spouse * No oocytes retrieved during oocyte retrieval * No blastocysts obtained on the 5th day of development * Embryo culture with transfer on the 2nd or 3rd day of development
Where it's running
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CHU de Clermont-Ferrand
Clermont-Ferrand, France Recruiting
Study contacts
- Principal investigator: Laure Chaput, PharmD, PhD — ART unit
- Study coordinator: Lise Laclautre
- Email: promo_interne_drci@chu-clermontferrand.fr
- Phone: 334.73.754.963
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.