Understanding how temperature affects male fertility through chromosome structures
Defining the Mechanisms of Temperature Sensitive Meiotic Chromosome Structures in Male Infertility
This study looks at how heat affects sperm production in males, using tiny worms to understand why higher temperatures might lead to infertility and possibly increase cancer risk, helping us learn more about male reproductive health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11290568 on NIH RePORTER |
What this research studies
This research investigates how temperature regulation impacts the formation of sperm in male organisms, specifically focusing on the mechanisms that lead to infertility when temperatures rise. Using the model organism Caenorhabditis elegans, the study examines the structural changes in meiotic chromosomes that occur under heat stress. By exploring these changes, the research aims to uncover the biological processes that contribute to male infertility and potentially increased cancer risk. The findings could provide insights into how temperature affects reproductive health in males.
Who could benefit from this research
Good fit: Ideal candidates for this research are males experiencing infertility issues potentially linked to temperature regulation.
Not a fit: Patients who are not experiencing infertility or have other unrelated reproductive health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing male infertility and associated health risks.
How similar studies have performed: While the specific mechanisms being studied may be novel, previous research has shown that temperature regulation is crucial for male fertility, indicating a foundation for potential success.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Cahoon, Cori K — Colorado State University
- Study coordinator: Cahoon, Cori K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.