Comparing sperm selection methods for intrauterine insemination

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot randomized control study aims to evaluate the effectiveness of two sperm preparation methods for couples undergoing intrauterine insemination (IUI). Participants will be randomly assigned to either the standard Density Gradient Centrifugation (DGC) method or the ZyMōt Multi (850µL) device. The primary outcome will be the live birth rate following the IUI procedures, assessing which method yields better results in terms of successful pregnancies. The study focuses on couples facing various infertility issues, including mild male factor infertility and unexplained infertility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Fresh autologous ejaculate
* Female age: \<37 at start of the first insemination
* 1st IUI ever here, maximum 3 consecutive IUIs during max 6 months
* BMI \<35
* All natural cycles, ovulation induction allowed
* Presence of 1 or 2 follicles at the last ultrasound
* Regular menses (26-35 days)
* \>1 million Total Progressive Motile Sperm Count (TPMC) after previous routine capacitation with DGC
* Presence of at least 1 potent tube after Hyfosy

Exclusion Criteria:

* Presence of intracavitary pathology at ultrasound
* Evidence of advance endometriosis (Grade 3 and 4)

Where it's running

• UZ Brussel CRG
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Shari Mackens, MD, PhD — Universitair Ziekenhuis Brussel
• Study coordinator: Elsie Nulens
• Email: elsie.nulens@uzbrussel.be
• Phone: 0032 2 4742676

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.