Exploring the link between genetic mutations and male infertility
GEMS: Genomic approach to connecting Elevated germline Mutation rates with male infertility and Somatic health
This study is looking at how higher rates of genetic changes in men might be linked to infertility and other health problems, and it involves men with varying fertility levels who will provide samples to help us understand these connections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11120851 on NIH RePORTER |
What this research studies
This research investigates how elevated germline mutation rates in men may be connected to male infertility and overall health issues. By analyzing genetic mutations in sperm and somatic tissues, the study aims to understand the relationship between infertility and increased risks of various cancers and other health conditions. The research will involve a unique population of men with different levels of fertility, allowing for a detailed examination of genetic factors that may contribute to their health outcomes. Patients may be asked to provide samples for genetic analysis to help uncover these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research are men experiencing infertility, particularly those with severe oligozoospermia or azoospermia.
Not a fit: Patients who are fertile and do not have any issues related to infertility are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for male infertility and associated health risks.
How similar studies have performed: Previous research has shown associations between genetic mutations and health risks in infertile men, suggesting that this approach has potential for meaningful insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Hotaling, James — University of Utah
- Study coordinator: Hotaling, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.