Comparing two types of transfer mediums for embryo implantation success
Use of Hyaluronic Acid-enriched Transfer Medium in Women Undergoing Single Blastocyst Transfer : a Multicenter, Randomized Controlled Trial
This study is testing if using a thicker gel called EmbryoGlue® helps more couples have healthy babies compared to a thinner gel during embryo transfers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 858 (estimated) |
| Sex | All |
| Sponsor | Northwest Women's and Children's Hospital, Xi'an, Shaanxi Academic / other |
| Locations | 1 site (Xi'an, Shaanxi) |
| Trial ID | NCT06492785 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of a high concentration Hyaluronic Acid transfer medium (EmbryoGlue®) compared to a lower concentration medium (G2 medium) in improving live birth rates during single fresh and frozen blastocyst transfers. Participants will be randomly assigned to receive either medium in a controlled manner, ensuring that the allocation is concealed from both couples and clinicians involved. The study will include cycles using autologous oocytes and will not impose age restrictions on participants. The outcomes will be assessed after the completion of data collection.
Who should consider this trial
Good fit: Ideal candidates include women undergoing single fresh or frozen blastocyst transfers using their own eggs.
Not a fit: Patients with uterine anatomical anomalies or untreated hydrosalpinx may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance live birth rates for women undergoing single blastocyst transfers.
How similar studies have performed: Other studies have explored the use of Hyaluronic Acid in embryo transfer, showing promising results, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. All cycles with single blastocyst transfer will be considered eligible 2. Both fresh and cryopreserved embryo transfer cycles utilizing autologous oocytes 3. No age restriction will be applied 4. Informed consent was signed Exclusion Criteria: 1. Uterine anatomic anomalies 2. Women with untreated hydrosalpines 3. Once couples have been enrolled in the trial, subsequent cycles will not be incorporated.
Where this trial is running
Xi'an, Shaanxi
- IVF laboratory — Xi'an, Shaanxi, China (Recruiting)
Study contacts
- Study coordinator: He Cai, Doctor
- Email: caihe@bjmu.edu.cn
- Phone: 13581613908
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.