Clinical trial Recruiting at 1 site Interventional

Comparing two types of transfer mediums for embryo implantation success

Official title: Use of Hyaluronic Acid-enriched Transfer Medium in Women Undergoing Single Blastocyst Transfer : a Multicenter, Randomized Controlled Trial

Run by Northwest Women's and Children's Hospital, Xi'an, Shaanxi · NCT06492785 · Data updated 2026-11-12

This study is testing if using a thicker gel called EmbryoGlue® helps more couples have healthy babies compared to a thinner gel during embryo transfers.

Quick facts

Study typeInterventional
SexAll
Enrollment858 (estimated)
SponsorNorthwest Women's and Children's Hospital, Xi'an, Shaanxi
Academic / other
Locations1 site (Xi'an, Shaanxi)
StatusRecruiting
StartedSeptember 13, 2024
Main results expectedDecember 31, 2025
Study endsDecember 31, 2025
Registry record updatedDecember 5, 2025
Trial IDNCT06492785 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include women undergoing single fresh or frozen blastocyst transfers using their own eggs.

Probably not a fit

Patients with uterine anatomical anomalies or untreated hydrosalpinx may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a high concentration Hyaluronic Acid transfer medium (EmbryoGlue®) compared to a lower concentration medium (G2 medium) in improving live birth rates during single fresh and frozen blastocyst transfers. Participants will be randomly assigned to receive either medium in a controlled manner, ensuring that the allocation is concealed from both couples and clinicians involved. The study will include cycles using autologous oocytes and will not impose age restrictions on participants. The outcomes will be assessed after the completion of data collection.

Why it matters

Potential benefit: If successful, this study could enhance live birth rates for women undergoing single blastocyst transfers.

How similar studies have gone: Other studies have explored the use of Hyaluronic Acid in embryo transfer, showing promising results, but this specific comparison is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. All cycles with single blastocyst transfer will be considered eligible
2. Both fresh and cryopreserved embryo transfer cycles utilizing autologous oocytes
3. No age restriction will be applied
4. Informed consent was signed

Exclusion Criteria:

1. Uterine anatomic anomalies
2. Women with untreated hydrosalpines
3. Once couples have been enrolled in the trial, subsequent cycles will not be incorporated.

Where it's running

  • IVF laboratory
    Xi'an, Shaanxi, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.