Comparing two types of transfer mediums for embryo implantation success
Official title: Use of Hyaluronic Acid-enriched Transfer Medium in Women Undergoing Single Blastocyst Transfer : a Multicenter, Randomized Controlled Trial
Run by Northwest Women's and Children's Hospital, Xi'an, Shaanxi · NCT06492785 · Data updated 2026-11-12
This study is testing if using a thicker gel called EmbryoGlue® helps more couples have healthy babies compared to a thinner gel during embryo transfers.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 858 (estimated) |
| Sponsor | Northwest Women's and Children's Hospital, Xi'an, Shaanxi Academic / other |
| Locations | 1 site (Xi'an, Shaanxi) |
| Status | Recruiting |
| Started | September 13, 2024 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | December 5, 2025 |
| Trial ID | NCT06492785 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include women undergoing single fresh or frozen blastocyst transfers using their own eggs.
✕Probably not a fit
Patients with uterine anatomical anomalies or untreated hydrosalpinx may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of a high concentration Hyaluronic Acid transfer medium (EmbryoGlue®) compared to a lower concentration medium (G2 medium) in improving live birth rates during single fresh and frozen blastocyst transfers. Participants will be randomly assigned to receive either medium in a controlled manner, ensuring that the allocation is concealed from both couples and clinicians involved. The study will include cycles using autologous oocytes and will not impose age restrictions on participants. The outcomes will be assessed after the completion of data collection.
Why it matters
Potential benefit: If successful, this study could enhance live birth rates for women undergoing single blastocyst transfers.
How similar studies have gone: Other studies have explored the use of Hyaluronic Acid in embryo transfer, showing promising results, but this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. All cycles with single blastocyst transfer will be considered eligible 2. Both fresh and cryopreserved embryo transfer cycles utilizing autologous oocytes 3. No age restriction will be applied 4. Informed consent was signed Exclusion Criteria: 1. Uterine anatomic anomalies 2. Women with untreated hydrosalpines 3. Once couples have been enrolled in the trial, subsequent cycles will not be incorporated.
Where it's running
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IVF laboratory
Xi'an, Shaanxi, China Recruiting
Study contacts
- Study coordinator: He Cai, Doctor
- Email: caihe@bjmu.edu.cn
- Phone: 13581613908
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.