Blocking a specific receptor to prevent infertility caused by chlamydia infections
Official title: TNFR2 blockade prevention of STI infertility
Funded at Yale University · NIH-10986536 · Data updated 2026-11-12
This study is looking at whether blocking a specific receptor can help prevent infertility caused by chlamydia infections, using mice to see how this might work and potentially help people dealing with infertility from STIs.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $335,000 |
| NIH project number | 1R21HD113862-01A1 |
| Project ID | NIH-10986536 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced infertility linked to chlamydia infections or pelvic inflammatory disease.
✕Less likely to help
Patients who do not have a history of chlamydia infections or related infertility issues may not benefit from this research.
What this research studies
This research investigates how blocking the TNFR2 receptor can prevent infertility associated with chlamydia infections. Using a mouse model, the study aims to understand the immunological effects of this blockade on pelvic inflammatory disease (PID) caused by Chlamydia trachomatis. The researchers will breed a specialized mouse colony and test various antibody variants to assess their effectiveness in preventing the harmful immune responses linked to chlamydia infections. This approach could lead to new therapeutic strategies for patients suffering from infertility due to STIs.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option to prevent infertility caused by chlamydia infections.
How similar studies have gone: While the approach of TNFR2 blockade is innovative, similar immunological strategies have shown promise in other contexts, suggesting potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Johnson, Raymond Morris — Yale University
- Study coordinator: Johnson, Raymond Morris
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.