Exploring how body clocks affect infertility caused by Chlamydia
Official title: Determining the role of circadian rhythms in Chlamydia associated tubal infertility
Funded at Morehouse School of Medicine · NIH-11074601 · Data updated 2026-11-12
This study is looking at how our body clocks might affect fertility issues caused by Chlamydia infections, using mice to see if the timing of the infection makes a difference in how severe the problem is, which could help us understand more about how to support those facing infertility.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morehouse School of Medicine NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 24, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $142,000 |
| NIH project number | 5R16AI175094-03 |
| Project ID | NIH-11074601 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility issues potentially linked to Chlamydia infections.
✕Less likely to help
Patients who do not have a history of Chlamydia infections or those whose infertility is caused by other factors may not benefit from this research.
What this research studies
This research investigates the connection between circadian rhythms, or body clocks, and tubal factor infertility caused by Chlamydia infections. The study aims to understand how the timing of infection influences the severity of the disease and its impact on fertility. By using genetically modified mice, researchers will examine the role of specific genes related to circadian rhythms in the progression of Chlamydia-related infertility. The findings could provide insights into how disruptions in natural body rhythms may exacerbate the effects of this infection.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infertility related to Chlamydia infections.
How similar studies have gone: While the specific focus on circadian rhythms in Chlamydia-related infertility is novel, previous research has shown that circadian rhythms can influence various biological processes and disease outcomes.
Where this research is happening
-
Morehouse School of Medicine
Atlanta, United States Active
Researchers
- Principal investigator: Omosun, Yusuf Oseobhunu — Morehouse School of Medicine
- Study coordinator: Omosun, Yusuf Oseobhunu
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Oral FSH receptor activator drugs to lower infertility treatment costs
A new oral drug approach aims to improve fertility treatments by using a small molecule that activates the FSH receptor, potentially making infertility care more affordable.
-
Prediction of ART outcomes for male factor infertility using single-molecule chromatin stenciling in sperm
A new test called sperm Fiber-seq is being developed to better predict how well ART will work for couples dealing with male-factor infertility.
-
TLR4 blocker for improving fertility in PCOS
A promising, already-approved drug (disulfiram) will be tested to see if it can reduce inflammation and improve ovulation in women with PCOS.
-
Innovative 3D-printed vaginal ring for progesterone delivery to support IVF pregnancies
A new 3D-printed vaginal ring delivers progesterone over 28 days for IVF patients, aiming to improve pregnancy success with fewer rings and less frequent dosing.
-
Genetics of Male Infertility: Accelerating Discovery and Clinical Impact
This grant aims to uncover the genetic causes of male infertility (azoospermia) to improve diagnosis and pave the way for personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.