Comparing timing of embryo transfer in women with recurrent implantation failure
Official title: A Randomized Controlled Trial Comparing Frozen Embryo Transfer Guided by Endometrial Receptivity Analysis Vs Standard Timing in Patients with Recurrent Implantation Failure
Run by The University of Hong Kong · NCT06762626 · Data updated 2026-11-12
This study is testing if timing frozen embryo transfers based on a special test can help women with repeated implantation failures get pregnant more successfully than using the usual timing methods.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 734 (estimated) |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | February 15, 2025 |
| Main results expected | December 30, 2027 |
| Study ends | June 30, 2028 |
| Registry record updated | March 26, 2025 |
| Trial ID | NCT06762626 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women under 40 years old with recurrent implantation failure who have at least one high-quality frozen blastocyst.
✕Probably not a fit
Patients with recurrent pregnancy loss, known chromosomal abnormalities, or certain uterine pathologies may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of endometrial receptivity analysis (ERA) in guiding the timing of frozen embryo transfers for women experiencing recurrent implantation failure (RIF). Participants will first undergo an endometrial biopsy to assess receptivity and will then be randomly assigned to either an ERA-guided transfer group or a standard timing group. The goal is to determine if timing the transfer based on ERA results can improve pregnancy rates compared to traditional methods. The trial is multicenter and double-blind, involving multiple hospitals across China.
Why it matters
Potential benefit: If successful, this approach could significantly increase pregnancy rates for women with recurrent implantation failure.
How similar studies have gone: While there is limited randomized controlled trial data on ERA's effectiveness in this context, similar approaches have shown promise in improving outcomes in other fertility-related studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Women with recurrent implantation failure 2. Women aged \< 40 years 3. Body mass index of women between 18.5 (inclusive) and 30 (exclusive) kg/m² 4. Women with at least one high quality frozen blastocyst (BB grade or above) and planning to undergo a single blastocyst transfer 5. Women who will give written informed consent Exclusion Criteria: 1. Women with recurrent pregnancy loss (3 or more biochemical or spontaneous miscarriages) 2. Either partner with known chromosomal abnormalities including balanced translocations 3. Women undergoing preimplantation genetic testing 4. Women with endometrial thickness \< 7 mm in the IVF cycle 5. Women with a confirmed diagnosis of stage III-IV endometriosis or adenomyosis affecting uterine cavity morphology 6. Women with a confirmed diagnosis of antiphospholipid syndrome 7. Pathologies affecting the uterine cavity, including polyps, submucosal fibroids, intramural fibroids \> 4 cm, or hydrosalpinx
Where it's running
-
The University of Hong Kong
Hong Kong, China Recruiting
Study contacts
- Study coordinator: Ernest HY Ng, MD
- Email: nghye@hku.hk
- Phone: +85222553400
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Mannose-binding lectin levels and repeated pregnancy or implantation failure
This project will test whether low blood levels of mannose-binding lectin are linked to repeated pregnancy loss, repeated failed embryo transfers after IVF/ICSI/FET, or other unexplained infertility in people with three consecutive pregnancy failures.
-
AI-assisted embryo selection on day 5 in IVF for infertility
This trial tests whether an AI-based embryo selection tool can help pick the best embryo for transfer on day 5 in IVF/ICSI to improve pregnancy chances for people with infertility.
-
Preserving sperm quality with aging through cryopreservation
This study tests whether freezing and thawing sperm can help keep younger-like DNA and molecular traits in men as they age.
-
Unstimulated Egg Retrieval with CAPA-IVM and Euploid Embryo Transfer
This study tests whether eggs can be collected without ovarian stimulation, matured in the lab, and used to create a single euploid embryo for transfer in infertility patients.
-
Ultra-Long GnRH-a Pretreatment Before Frozen Embryo Transfer for Deep Infiltrating Endometriosis
In people under 40 with deep infiltrating endometriosis and infertility, the study tests whether two injections of a GnRH agonist before hormone support improve pregnancy outcomes in their first frozen-thawed embryo transfer.
-
Endometrial Waves and Pregnancy in FET Cycles with Hormone Therapy
This study tests whether patterns of uterine contractions during hormone-prepared frozen embryo transfer affect pregnancy outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.