Body clock's role in Chlamydia-linked fallopian tube infertility
Determining the role of circadian rhythms in Chlamydia associated tubal infertility
['FUNDING_OTHER'] · MOREHOUSE SCHOOL OF MEDICINE · NIH-11326267
This project looks at whether your body's internal clock affects how Chlamydia infections can damage the fallopian tubes and lead to infertility.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MOREHOUSE SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11326267 on ClinicalTrials.gov |
What this research studies
Chlamydia infections can cause damage to the fallopian tubes that leads to infertility, and the researchers found that the time of day influences infection severity in prior work. In the lab they use mouse models, including a jet-lag model that disrupts circadian rhythms, and have seen more infectivity and tissue damage when rhythms are disturbed. The team will use genetically modified mice missing key clock genes (Bmal1, Per2, Cry1) to see how those genes change infection outcomes and will study which genes, proteins, and miRNAs are turned on or off. Results are intended to point toward whether timing or clock-related biology could be used to prevent or reduce Chlamydia-related tubal damage in people.
Who could benefit from this research
Good fit: Women with a history of Chlamydia infection, recurrent pelvic inflammatory disease, or unexplained tubal infertility would be most relevant to this research.
Not a fit: People without prior Chlamydia infections or those whose infertility is due to non-tubal causes are unlikely to see direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could lead to timing-based approaches or new treatments to prevent or limit Chlamydia-related fallopian tube damage and infertility.
How similar studies have performed: Animal studies, including work from this group, suggest circadian disruption changes infection severity, but applying this to human infertility remains largely untested.
Where this research is happening
ATLANTA, UNITED STATES
- MOREHOUSE SCHOOL OF MEDICINE — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OMOSUN, YUSUF OSEOBHUNU — MOREHOUSE SCHOOL OF MEDICINE
- Study coordinator: OMOSUN, YUSUF OSEOBHUNU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Sexually Transmitted Diseases, Bacterial Venereal Diseases