Impact of PICSI on embryo quality in infertility treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of Physiologic Intracytoplasmic Sperm Injection (PICSI) on the euploidy rates of embryos in couples undergoing assisted reproductive technology. By selecting sperm based on their ability to bind to hyaluronic acid, the study aims to improve sperm quality and ultimately enhance embryo viability. Couples with specific age criteria and a minimum number of mature eggs will be included, while those using donor or frozen gametes will be excluded. The study builds on previous findings that suggest PICSI may reduce miscarriage rates, despite mixed results regarding live birth rates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Couples undergoing a planned ICSI-PGT-A cycle using their own fresh gametes
* Female age \> 35 years and/or Male age \> 40 years
* Minimum of two mature eggs at time of egg maturity assessment

Exclusion Criteria:

* Couples undergoing a planned IVF cycle (even if converted to ICSI)
* Patients using donor gametes for an ICSI cycle
* Patients using frozen gametes for an ICSI cycle

Where it's running

• Merrion Fertility Clinic
  Dublin, Dublin, Ireland Recruiting

Study contacts

• Study coordinator: Louise E Glover, PhD
• Email: lglover@merrionfertility.ie
• Phone: 353 + 15567900

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ultra-Long GnRH-a Pretreatment Before Frozen Embryo Transfer for Deep Infiltrating Endometriosis

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• Endometrial Waves and Pregnancy in FET Cycles with Hormone Therapy

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  Recruiting Mỹ Đức Hospital · Ho Chi Minh City · NCT07675213

• Environmental and lifestyle factors linked to ART success in infertility patients

  This study follows 5,000 infertile men and women to see how environmental exposures and lifestyle relate to the success of assisted reproductive technology.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07641387

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.