Using hyaluronan-enriched medium to improve embryo transfer outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of a hyaluronan-enriched medium, known as EmbryoGlue, on the pregnancy outcomes of euploid blastocyst transfers during frozen embryo transfer (FET) cycles. The trial will involve women aged 18 to 46 who have undergone preimplantation genetic testing for aneuploidy (PGT-A) and have at least one chromosomally normal blastocyst available for transfer. The study is designed to be double-blinded, ensuring that both patients and doctors are unaware of the treatment being administered. The primary goal is to determine if exposure to EmbryoGlue prior to and during transfer enhances implantation rates and overall pregnancy success. Interim analyses will be conducted to assess the trial's progress and efficacy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All frozen embryo transfer (FET) cycles with euploid blastocysts biopsied and vitrified on Day 5 after PGT-A.
* Rank of randomization based on embryo quality.
* Only hormonal replacement theraphy (HRT) cycle regimen.
* Women aged 18 years to 46 years.
* Having at least 1 chromosomally normal vitrified blastocyst(s) on Day 5 available for transfer.
* All sperm samples.
* BMI between 18 and 35.

Exclusion Criteria:

* FET cycles with preimplantation genetic testing for monogenic disorders (PGT-M) and for structural rearrangements (PGT-SR).
* FET cycles with mosaic / aneuploid blastocysts.
* FET cycles with unknown outcome.
* FET cycles with Day 6 or Day 7 biopsied blastocysts.
* FET with patients' endometrium preparation with treatments other than HRT.
* FET where PGT-A was performed for gender selection.

Where it's running

• ART Fertility Clinics LLC
  Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates Recruiting

Study contacts

• Study coordinator: Daniela Nogueira
• Email: daniela.nogueira@artfertilityclinics.com
• Phone: +971504374961

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.