Treatment to improve fertilization in infertility cases
Gamete Treatment to Correct Fertilization Failure
This study is testing a new way to help couples struggling with infertility by improving the chances of fertilization and embryo development.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1200 (estimated) |
| Ages | 21 Years to 89 Years |
| Sex | All |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT01944332 on ClinicalTrials.gov |
What this trial studies
This research focuses on enhancing fertilization rates in patients experiencing infertility due to fertilization failure. The study involves preparing sperm using a membrane permeabilizing agent and injecting it into oocytes, which are then activated to promote embryo development. The efficacy of this gamete treatment will be assessed by monitoring fertilization success and embryo development over a standard culture period. The goal is to provide a viable option for patients who have previously faced fertilization challenges.
Who should consider this trial
Good fit: Ideal candidates include patients who have experienced complete fertilization failure with standard IVF or have had one prior ICSI treatment cycle.
Not a fit: Patients who do not meet the inclusion criteria or those who have undergone IVF without ICSI may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve the chances of conception for patients facing fertilization failure.
How similar studies have performed: Other studies have shown promise with similar gamete treatment approaches, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with complete fertilization failure with standard IVF or failure with one prior ICSI treatment cycle Exclusion Criteria: * not meeting inclusion criteria * IVF without ICSI
Where this trial is running
New York, New York
- Center fo Reproductive Medicine — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Gianpiero Palermo, MD, MPH — Weill Medical College of Cornell University
- Study coordinator: Rodriq Stubbs, NP
- Email: res2011@med.cornell.edu
- Phone: 646-962-3276
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.