How anticoagulant medicines affect the uterine lining and pregnancy chances in women with infertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, prospective observational cohort that will follow about 300 infertile women aged 20–45 who are planning embryo transfer or monitored conception cycles. Participants will be observed in two groups based on whether they receive routine anticoagulant therapy (for example, low-dose aspirin or heparin) as part of their clinical care, with no treatment decisions made by the study team. A multimodal ultrasound system (2D, 3D and Doppler) will be used to measure endometrial thickness, morphology, peristalsis, and blood flow indices during the implantation window. Pregnancy status and outcomes will be followed at roughly 45 and 90 days of gestation to compare ultrasound-based receptivity indicators and early pregnancy results between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female patients aged 20 to 45 years.

Clinically diagnosed with infertility and planning to undergo embryo transfer or monitored conception cycles.

Patients who have complete baseline clinical data and are willing to undergo multimodal ultrasound evaluation of endometrial receptivity during the window of implantation.

Voluntarily agreed to participate in this observational study and signed the informed consent form for data collection.

Exclusion Criteria:

* Presence of congenital uterine malformations (e.g., septate uterus, bicornuate uterus, unicornuate uterus) that significantly alter the endometrial cavity.

Presence of untreated severe intrauterine lesions, such as submucosal fibroids, severe intrauterine adhesions, or endometrial polyps that may mechanically interfere with implantation.

Severe underlying systemic diseases, including but not limited to severe liver or kidney dysfunction, or malignant tumors.

Known severe bleeding disorders or strict contraindications to anticoagulant medications (for patients in the routine clinical care setting).

Patients who are unable to cooperate with the transvaginal multimodal ultrasound examination or complete the required follow-up for pregnancy outcomes.

Where it's running

• Tangdu Hospital, Air Force Medical University
  Xi'an, Shaanxi, China Recruiting

Study contacts

• Principal investigator: Li Zhang, MD — Tang-Du Hospital
• Study coordinator: Li Zhang, MD
• Email: lilyzhang319_20@hotmail.com
• Phone: 86-29-84778860

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.