Condition
Cardiac Arrest clinical trials and research
As of November 12, 2026, Find a Trial lists 56 Cardiac Arrest clinical trials that are recruiting, at sites in 25 countries (most in United States (15), France (10), China (8)). By phase: Phase 4 (3), Phase 3 (3), Phase 1 (2), Phase 2 (1). The most active sponsors are National Taiwan University Hospital (3), Capital Medical University (3), Nantes University Hospital (3). There are also 88 NIH-funded research projects on Cardiac Arrest, with $50.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 56Clinical trials
- 88NIH research projects
- 25Countries
Newest Cardiac Arrest clinical trials
All recruiting trials (56)
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Heartsight helps caregivers of kids after cardiac arrest manage uncertainty and fear
This pilot trial tests if the Heartsight information program is acceptable and helpful for caregivers of children who recently had a cardiac arrest.
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Brain blood flow and brain regulation in critically ill kids
This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.
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Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients
This trial will test whether adding a balloon occlusion of the descending aorta (REBOA) to standard ACLS helps people having an in-hospital cardiac arrest regain and keep a pulse.
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Digital serious game to improve critical care nurses' targeted temperature management skills and situational awareness.
We will test whether adding a digital serious game to regular lectures helps adult ICU nurses learn targeted temperature management and improve situational awareness.
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Plasma proteins, metabolites, and platelet changes in extracorporeal CPR for cardiac arrest patients
This project will test whether patterns in blood proteins, small molecules, and platelet shape changes can help identify which adults with cardiac arrest might benefit from extracorporeal CPR.
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Targeted Temperature Management at 33°C for in-hospital cardiac arrest
This trial tests whether cooling patients who remain unconscious after a resuscitated in-hospital cardiac arrest to 33°C improves survival with good brain function compared to keeping a normal, controlled temperature.
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Goal-directed neuroprotection bundle for adults after cardiac arrest
This trial will test whether a goal-directed bundle of treatments (temperature, breathing gases, position, blood pressure, glucose, sodium and lactate control) helps adults who are unconscious after return of circulation from cardiac arrest recover their brain function better than usual care.
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How oxygen levels relate to when circulation stops during controlled (Maastricht III) organ donation
This research will test how oxygen levels change around the time the heart stops in adults who undergo controlled Maastricht III organ donation.
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Investigating left ventricle unloading during extracorporeal life support
This study looks at how different methods of relieving pressure on the heart can help patients on a special life support system called VA ECLS, especially those in serious heart trouble.
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Target-directed management of brain oxygenation after ECPR
This study tests whether monitoring cerebral oxygen levels during ECPR can help guide care to improve brain outcomes after cardiac arrest.
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Testing earlier amiodarone administration in cardiac arrest
This study tests if giving amiodarone two minutes earlier during out-of-hospital cardiac arrest can help improve survival and brain function for patients with serious heart rhythms.
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Initial double sequential defibrillation for out-of-hospital ventricular fibrillation
This trial will test whether using two defibrillators to give double sequential shocks first improves survival for adults with out-of-hospital cardiac arrest and a shockable rhythm.
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Combined whole-brain MRI to predict recovery after cardiac arrest
This study tests whether personalized whole-brain MRI connectivity maps can better predict six-month neurological recovery in adults who remain unconscious after cardiac arrest compared with standard predictors.
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Monitoring and optimizing brain blood flow in patients after cardiac arrest
This study is testing a way to monitor and improve blood flow in the brain for patients who have survived cardiac arrest to see if it helps their recovery.
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Measuring air volumes delivered during in-hospital cardiac arrest
This study tests how much air gets delivered to patients' lungs during CPR in the hospital to see which airway devices work best for helping them breathe.
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Examining energy use in cardiac arrest patients undergoing temperature management
This study is testing how much energy cardiac arrest patients need while they are being cooled down in the ICU to see if different temperatures affect their recovery.
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Butylphthalide for improving brain function after cardiac arrest
This study is testing if butylphthalide can help improve brain function in people who have survived cardiac arrest.
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Innovative technologies to improve cardiac arrest resuscitation effectiveness
This study is testing new technology, like smartphone apps and wearable devices, to see if it can help improve CPR and defibrillation for people who have a cardiac arrest outside of the hospital.
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Using real-time feedback to improve ventilation during cardiac arrest.
This study tests if giving real-time feedback on breathing during cardiac arrest helps improve the effectiveness of ventilation for patients in need of resuscitation.
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Continuous jugular venous oxygen saturation monitoring after cardiac arrest
This project will test continuous and intermittent jugular venous oxygen saturation monitoring in adults who are comatose after cardiac arrest to see if brain oxygen delivery patterns can be detected and tracked.
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Effect of phosphocreatine on patients treated by medical emergency teams
This study tests if giving phosphocreatine to hospitalized patients with serious conditions can help them recover faster and shorten their hospital stays compared to those who receive a placebo.
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Using magnesium to protect the brain after cardiac arrest
This study is testing if giving magnesium to people who have survived a cardiac arrest can help protect their brain and reduce injury.
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Brain MRI markers after cardiac arrest to see if they predict good recovery
This observational study tests whether advanced brain MRI measures can help predict who will recover brain function after a comatose cardiac arrest.
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Internet-based interventions for cardiac arrest survivors
This study tests whether a web app that offers lifestyle support can help people who survived a cardiac arrest feel less anxious and depressed, and improve their overall quality of life.
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Assessing brain injury in cardiac arrest patients
This study is trying to find a better way to check for brain injuries in patients who have had a cardiac arrest to help decide who needs special treatments to improve their recovery.
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Evaluating Butylphthalide for Neurological Recovery After Cardiac Arrest
This study is testing if a medication called Butylphthalide can help improve brain function in people who have survived a cardiac arrest.
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Investigating brain-heart interactions after cardiac arrest
This study is trying to understand how the brain and heart work together in patients who have survived cardiac arrest to see if it can help predict their recovery.
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Drone-delivered AEDs for cardiac arrests in rural areas
This project tests whether delivering AEDs by emergency drones to out-of-hospital cardiac arrest sites can reach patients faster than current first responders and EMS in rural communities.
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Prehospital epinephrine, vasopressin, and steroid for out-of-hospital cardiac arrest
This trial tests whether giving epinephrine together with vasopressin and a steroid in the ambulance helps adults with non‑traumatic out‑of‑hospital cardiac arrest in Taipei and New Taipei City achieve sustained return of spontaneous circulation.
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Using heart rate variability to predict brain injury after cardiac arrest
This study is testing if measuring heart rate variability can help doctors predict brain injury in patients who have had a cardiac arrest and are in the ICU.
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Registry of brain-heart comorbidity in China
This study is trying to build a big database to better understand and manage the connection between brain and heart problems in people across China.
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Improving survival rates for out-of-hospital cardiac arrest using advanced CPR techniques
This study is testing new CPR techniques and devices to see if they can help adults who have a cardiac arrest outside of the hospital survive and maintain normal brain function.
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AI analysis of ECGs for high-risk cardiac patients
This study is testing an AI tool that analyzes heart rhythm patterns in high-risk heart patients to see if it can help doctors catch problems earlier and improve patient care.
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Aerosol box use during cardiopulmonary arrest
This project tests whether using an aerosol box during emergency airway procedures and chest compressions lowers particle spread and is practical for healthcare teams treating cardiac arrest patients, including those with COVID-19.
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Early assessment of brain recovery after cardiac arrest
This study is testing if doctors can predict brain recovery sooner than usual for adults who have had a cardiac arrest by using a mix of exams and tests within 24 hours.
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Assessing early brain damage in cardiac arrest patients upon ICU admission
This study is testing ways to measure early brain damage in adults who are in a coma after cardiac arrest to help doctors make better decisions about their care.
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Testing inhaled hydrogen gas for cardiac arrest treatment
This study is testing if breathing in hydrogen gas can help improve recovery for patients who have had a cardiac arrest and are receiving special life-saving treatment.
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Comparing Doppler Ultrasound and Manual Pulse Checks in Cardiac Arrest
This study is testing a new device that uses ultrasound to check blood flow in the neck of cardiac arrest patients to see if it can accurately tell when their heart starts beating again.
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Evaluating how quickly EMS recognizes cardiac arrest calls
This study looks at how quickly emergency services recognize cardiac arrest calls to see if improving this timing can help save lives.
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Effects of mean arterial pressure on outcomes after out-of-hospital cardiac arrest
This study tests if keeping blood pressure at a higher level after a cardiac arrest can help patients recover better and survive longer.
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Registry of cardiac arrests in children with congenital heart disease
This study is collecting information on cardiac arrests in children with congenital heart disease in Germany to see how these events affect their recovery and overall health.
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Improving survival rates for cardiac arrest patients with Pulseless Electrical Activity
This study is testing if a special type of fluid with low sodium can help improve survival rates for patients who have a cardiac arrest with pulseless electrical activity.
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Rehabilitation program for survivors of out-of-hospital cardiac arrest
This study tests if a personalized rehabilitation program can help people who survived a cardiac arrest return to work better than just regular care alone.
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Using vasopressin and steroids with adrenaline for cardiac arrest treatment
This study is testing if adding vasopressin and steroids to standard adrenaline treatment can help improve survival rates for patients who have a cardiac arrest in the hospital.
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Infusion of sodium lactate after cardiac arrest
This study is testing if giving a special solution called sodium lactate to patients who have just been revived from cardiac arrest can help protect their brain and reduce damage.
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Evaluating the use of transesophageal echocardiography in critically-ill patients
This study tests how using a special heart ultrasound called transesophageal echocardiography can help critically-ill patients in emergency and intensive care settings.
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International registry for pediatric in-hospital cardiac arrest outcomes
This study is creating a global registry to track the outcomes of children who have cardiac arrests in hospitals, to see how well they survive and recover after treatment.
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Identifying factors that predict survival and neurological outcomes in patients treated with E-CPR.
This study looks at patients who received ECMO treatment after a cardiac arrest to see what factors can help predict their survival and brain recovery.
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Registry of extracorporeal life support cases in China
This study collects information on patients using extracorporeal life support (ECLS) in China to see how well it helps with heart and lung problems over time.
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Comparing two CPR methods for out-of-hospital cardiac arrest
This study is testing whether Chest Compression Only CPR is just as effective as Standard CPR for helping people who have a cardiac arrest outside of the hospital.
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Registry of patients needing ECMO in Australia and New Zealand
This study is creating a detailed database of patients in Australia and New Zealand who need ECMO for serious heart or lung problems to help improve treatment and outcomes for critically ill patients.
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Registry of cardiac arrest cases at Versailles Hospital
This study collects information on patients who have cardiac arrest to see what factors affect their recovery and outcomes.
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Registry and tissue repository for comatose cardiac arrest patients
This study is trying to find a way to better predict how well comatose patients will recover after a cardiac arrest by collecting important information about their care and outcomes.
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Evaluating pediatric resuscitation quality across multiple centers
This study is testing how different techniques of chest compressions during CPR can improve survival and brain health for children who have a cardiac arrest.
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Investigating inflammation and metabolism after cardiac arrest
This study looks at how inflammation and metabolism change after cardiac arrest to see if they affect recovery and brain health in patients.
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Collecting samples from patients with sepsis or after cardiac arrest
This study is testing blood samples from patients with sepsis or who have just been revived from cardiac arrest to see if they can find new treatments that help improve recovery.
NIH-funded research (newest 40 of 88)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
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Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
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Pediatric cooling duration to improve brain recovery after out-of-hospital cardiac arrest
This study tests the best length of cooling after cardiac arrest in children to help more kids recover with better brain function.
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Pediatric cooling duration to improve brain outcomes after cardiac arrest
This project tests whether different durations of cooling after a child’s cardiac arrest can lead to better brain recovery.
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Ventilation during CPR and outcomes in out-of-hospital cardiac arrest
This project will look at how ventilation during CPR relates to survival in adults who have a cardiac arrest outside the hospital.
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Addressing disparities in out-of-hospital cardiac arrest using health needs and predictive analytics
A physician-scientist project uses data from OHCA patients and language-based AI tools to improve predictions of survival and identify social needs that influence outcomes.
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Dual-setting airway device to support heart attack survivors and after-resuscitation patients
A new adjustable breathing aid device helps improve blood flow and brain protection during and after cardiac arrest, aiming to increase survival with good brain function.
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Physiology-guided Epinephrine Dosing for Pediatric Cardiac Arrest
Researchers are testing personalized epinephrine dosing during pediatric cardiac arrest to improve outcomes for children in the hospital.
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Aging and brain injury after cardiac arrest: how age changes brain response
Doctors are studying how aging affects the brain after a cardiac arrest and what this could mean for preventing or treating brain injury.
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Interhospital differences in cardiac arrest care and outcomes
This NIH career development grant supports a clinician-researcher as they study how care in different hospitals affects survival and outcomes for people who have an out-of-hospital cardiac arrest, with a focus on African American, Hispanic/Latino, and low-income communities.
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Protecting thalamic neurons after cardiac arrest with ethosuximide
A new, patient-friendly approach looks at giving ethosuximide after cardiac arrest to protect brain cells that help consciousness, aiming to improve recovery for survivors.
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IQ-CART: Improving Cardiac Arrest Outcomes Through Resuscitation Academy Training
A study to see if EMS agencies that participate in Resuscitation Academy training have better survival rates after out-of-hospital cardiac arrests.
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Targeting brain inflammation after global brain injury from cardiac arrest
This grant tests a new treatment aimed at reducing brain inflammation after cardiac arrest to protect memory and thinking in people who survive a cardiac arrest.
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Tailored 9-1-1 CPR Guidance to Improve Pediatric bystander Response in Alabama
A pediatric OHCA project tests a customized T-CPR script to help 9-1-1 call takers guide bystanders to perform CPR in Alabama communities.
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Intravenous oxygen for cardiac arrest
This project tests whether tiny oxygen-filled particles given through a vein can quickly raise oxygen levels during cardiac arrest to help people survive and reduce brain injury.
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Tiny oxygen-filled bubbles given into a vein to supply oxygen during cardiac arrest and severe organ oxygen loss
This project explores giving oxygen-rich saline containing microscopic bubbles into the bloodstream to help children and adults during cardiac arrest or when organs are not getting enough blood and oxygen.
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Sedation and brain recovery after cardiac arrest
This project looks at whether different sedation approaches help adults recover brain function after a cardiac arrest.
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AI-powered ECG tool to quickly detect and predict ventricular tachycardia during in-hospital cardiac arrest
A new AI-enhanced ECG algorithm is being developed to rapidly identify and forecast dangerous ventricular rhythms in adults with in-hospital cardiac arrest, aiming to improve defibrillation timing.
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Improving breathing during CPR for children
This project trains hospital teams to use cue cards and a metronome so providers give guided, faster breaths during pediatric CPR to try to help more children survive cardiac arrest.
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Better recovery predictions after cardiac arrest
This project develops computer tools to give faster, clearer recovery outlooks for people who are comatose after a cardiac arrest.
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Limiting oxygen after cardiac arrest to protect the brain and heart
This project gives lower oxygen to patients right after cardiac arrest to try to reduce oxygen-related damage and help the heart and brain recover.
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Treating the immune reaction after cardiac arrest
This work tests therapies to calm the immune response in adults who are resuscitated from cardiac arrest to help reduce organ damage and death.
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Mitochondrial DNA differences linked to sudden cardiac arrest risk and recovery
This research looks at whether differences in mitochondrial DNA affect a person's risk of sudden cardiac arrest and their chances of recovery after resuscitation.
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Immune cell protection after cardiac arrest
This project looks at whether immune cells that produce adenosine can calm inflammation and help people recover after cardiac arrest.
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How the immune system calms inflammation after cardiac arrest
Researchers are exploring how immune cells and signals calm inflammation after out-of-hospital cardiac arrest to protect the brain and improve recovery.
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Improving survival rates after cardiac arrest using new techniques
This study is looking at new ways to help people who have had a cardiac arrest and aren't responding to regular CPR, by trying a combination of techniques that could improve blood flow to the brain and vital organs, giving them a better chance of survival.
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Improving predictions of brain recovery after cardiac arrest
This project aims to help doctors make more accurate predictions about brain recovery for people who survive a cardiac arrest by comparing outcomes in the U.S. and Brazil.
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Protecting Brain Cells that Control Consciousness After Cardiac Arrest
This project explores if a medication called ethosuximide can protect important brain cells and improve consciousness for people after cardiac arrest.
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Inhaling argon gas during CPR to protect organs and improve survival after cardiac arrest
This work gives argon gas during CPR to people who have a cardiac arrest to help protect their brain and heart and improve chances of survival.
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Cooling time and recovery after pediatric cardiac arrest
This project tests whether keeping children colder for longer after out-of-hospital cardiac arrest helps their brains recover better.
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How long cooling helps children after cardiac arrest
This research sees if longer targeted cooling after an out-of-hospital cardiac arrest helps children survive and recover brain function.
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How race and ethnicity relate to survival and emergency treatments after in-hospital cardiac arrest
This project looks at whether differences in emergency treatments during in-hospital cardiac arrest help explain why Black, Hispanic, and White adults have different survival outcomes.
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A New Treatment for Brain Inflammation After Cardiac Arrest
This project looks for new ways to protect the brain and improve memory after someone experiences a cardiac arrest.
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Investigating how race and ethnicity affect emergency care for cardiac arrest
This study looks at how emergency medical services treat people who have a cardiac arrest outside of the hospital, focusing on differences between racial and ethnic groups, to find ways to improve care and help everyone have a better chance of survival.
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Personalized epinephrine dosing for children during in-hospital cardiac arrest
This project gives epinephrine doses based on a child's blood pressure during in-hospital cardiac arrest to try to help doctors restart the heart in children.
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Using intravenous oxygen to treat cardiac arrest
This study is testing a new way to deliver oxygen directly into the bloodstream during cardiac arrest, which could help patients who are struggling to breathe, using tiny bubbles that release oxygen safely when injected.
Related topics
Quick answers
How many Cardiac Arrest clinical trials are recruiting right now?
56, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 25 countries. The most sites are in United States (15 trials), France (10 trials), China (8 trials), Italy (5 trials), Taiwan (4 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 4: 3, Phase 3: 3, Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.