Prehospital epinephrine, vasopressin, and steroid for out-of-hospital cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized prehospital clinical trial comparing standard epinephrine alone to a combination of epinephrine, vasopressin, and methylprednisolone administered by trained paramedics. The combination arm uses standard epinephrine doses with 20 U vasopressin after each epinephrine dose (up to 80 U) and a single 40 mg dose of methylprednisolone after the first epinephrine. The primary outcome is sustained return of spontaneous circulation (ROSC) and secondary outcomes include longer-term survival. The trial plans to enroll about 1,344 adult non‑traumatic OHCA patients treated by EMS in Taipei City and New Taipei City.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (aged \>= 18 )
* Out-of-hospital cardiac arrest in the studied regions
* Treated by paramedics authorized and capable of giving prehospital medication

Exclusion Criteria:

* OHCA with traumatic etiology
* Obvious signs of death like decapitation, rigor mortis, livor mortis, decomposition, etc.
* DNR (Do Not Resuscitation) or termination of resuscitation requested by the family
* Patients with known or suspected pregnancy
* No vascular access was established before hospital arrival
* ROSC before the administrated medication
* No patient contact (cancelled ambulance call or the patient was transported to the hospital before the arrival of trial-trained paramedics)
* Received epinephrine prior to the arrival of trial-trained paramedics

Where it's running

• National Taiwan University Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Principal investigator: WEN CHU CHIANG, Phd — National Taiwan University Hospital
• Study coordinator: WEN CHU CHIANG, PhD
• Email: drchiang.tw@gmail.com
• Phone: +886 926131851

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.