Physiology-guided Epinephrine Dosing for Pediatric Cardiac Arrest
Official title: Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest (PEDICA)
Funded at Children's Hosp of Philadelphia · NIH-11398884 · Data updated 2026-11-12
Researchers are testing personalized epinephrine dosing during pediatric cardiac arrest to improve outcomes for children in the hospital.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $758,214 |
| NIH project number | 5R01HL175433-03 |
| Project ID | NIH-11398884 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children in hospitals experiencing in-hospital cardiac arrest who require epinephrine during resuscitation and whose care teams are using physiology-guided strategies.
✕Less likely to help
Children whose IHCA events do not follow the patterns targeted by physiology-directed dosing or who are not candidates for epinephrine-based resuscitation may not benefit.
What this research studies
This project aims to move beyond one-size-fits-all CPR by using each child’s physiology to guide epinephrine dosing during pediatric in-hospital cardiac arrest. It builds on recent findings that how a child’s blood pressure responds to the first dose of epinephrine may relate to better chances of recovery. The team will study real-time physiological data to tailor dosing and improve the likelihood of return of spontaneous circulation. The work is conducted at a major children's hospital, led by a pediatric cardiology and resuscitation research team, and seeks to inform future clinical practice for IHCA care.
Why it matters
Potential benefit: If successful, this approach could increase survival with better neurological outcomes for children experiencing IHCA by personalizing treatment.
How similar studies have gone: Prior work suggests that tailoring CPR interventions based on physiological responses can influence circulation and outcomes, but this specific pediatric, physiology-directed dosing approach is advancing toward clinical application.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Morgan, Ryan William — Children's Hosp of Philadelphia
- Study coordinator: Morgan, Ryan William
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
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Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.