Improving survival rates for out-of-hospital cardiac arrest using advanced CPR techniques
Cardiac Arrest Bundle of Care Trial
This study is testing new CPR techniques and devices to see if they can help adults who have a cardiac arrest outside of the hospital survive and maintain normal brain function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 32 (estimated) |
| Ages | 18 Years to 120 Years |
| Sex | All |
| Sponsor | University Hospital Southampton NHS Foundation Trust Academic / other |
| Locations | 1 site (Southampton, England) |
| Trial ID | NCT05917717 on ClinicalTrials.gov |
What this trial studies
This trial focuses on enhancing survival rates for patients experiencing out-of-hospital cardiac arrest by utilizing a combination of advanced resuscitation devices. The intervention includes head-up position CPR, active compression-decompression mechanical CPR, and an impedance threshold device, all aimed at improving blood flow during resuscitation. The study targets adult patients who have suffered a witnessed cardiac arrest and aims to assess the effectiveness of this 'bundle of care' approach in increasing survival rates with normal brain function. By leveraging promising data from previous studies, the trial seeks to address the historically low survival rates associated with out-of-hospital cardiac arrests.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have suffered a witnessed cardiac arrest within 20 minutes of collapse.
Not a fit: Patients who are visibly pregnant, have experienced traumatic cardiac arrest, or have been in cardiac arrest for more than 21 minutes are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly increase survival rates and improve neurological outcomes for patients who experience out-of-hospital cardiac arrest.
How similar studies have performed: Previous studies have shown promising results with similar advanced resuscitation techniques, indicating potential for success in this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult patients (\>18 year of age) who have suffered a cardiac arrest 2. Body habitus is compatible with the bundle devices. 3. Witnessed event 4. Time of collapse was known with reasonable certainty to have been to be within 20 minutes. Exclusion Criteria: 1. Visibly pregnant women 2. Prisoners 3. Traumatic cardiac arrest 4. Drowning 5. Hanging 6. DNACPR 7. Have been in witnessed cardiac arrest for an estimated time of 21 minutes or more
Where this trial is running
Southampton, England
- University Hospital Southampton NHS Foundation trust — Southampton, England, United Kingdom (Recruiting)
Study contacts
- Principal investigator: James Plumb, PhD — University Hospital Southampton NHS Foundation Trust
- Study coordinator: James OM Plumb, PhD
- Email: j.plumb@soton.ac.uk
- Phone: 07967319438
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.