Improving survival rates for out-of-hospital cardiac arrest using advanced CPR techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial focuses on enhancing survival rates for patients experiencing out-of-hospital cardiac arrest by utilizing a combination of advanced resuscitation devices. The intervention includes head-up position CPR, active compression-decompression mechanical CPR, and an impedance threshold device, all aimed at improving blood flow during resuscitation. The study targets adult patients who have suffered a witnessed cardiac arrest and aims to assess the effectiveness of this 'bundle of care' approach in increasing survival rates with normal brain function. By leveraging promising data from previous studies, the trial seeks to address the historically low survival rates associated with out-of-hospital cardiac arrests.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult patients (\>18 year of age) who have suffered a cardiac arrest
2. Body habitus is compatible with the bundle devices.
3. Witnessed event
4. Time of collapse was known with reasonable certainty to have been to be within 20 minutes.

Exclusion Criteria:

1. Visibly pregnant women
2. Prisoners
3. Traumatic cardiac arrest
4. Drowning
5. Hanging
6. DNACPR
7. Have been in witnessed cardiac arrest for an estimated time of 21 minutes or more

Where it's running

• University Hospital Southampton NHS Foundation trust
  Southampton, England, United Kingdom Recruiting

Study contacts

• Principal investigator: James Plumb, PhD — University Hospital Southampton NHS Foundation Trust
• Study coordinator: James OM Plumb, PhD
• Email: j.plumb@soton.ac.uk
• Phone: 07967319438

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Initial double sequential defibrillation for out-of-hospital ventricular fibrillation

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• Innovative technologies to improve cardiac arrest resuscitation effectiveness

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• Prehospital epinephrine, vasopressin, and steroid for out-of-hospital cardiac arrest

  This trial tests whether giving epinephrine together with vasopressin and a steroid in the ambulance helps adults with non‑traumatic out‑of‑hospital cardiac arrest in Taipei and New Taipei City achieve sustained return of spontaneous circulation.

  Recruiting National Taiwan University Hospital · Taipei · NCT06203847

• Rehabilitation program for survivors of out-of-hospital cardiac arrest

  This study tests if a personalized rehabilitation program can help people who survived a cardiac arrest return to work better than just regular care alone.

  Recruiting Phase 4 Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05173740

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.