Brain MRI markers after cardiac arrest to see if they predict good recovery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses advanced MRI techniques, including stimulus-based fMRI, resting-state fMRI, and diffusion tensor imaging, to explore associations with favorable neurological outcomes at 6 months in comatose survivors of cardiac arrest. Analyses will adjust for age, initial GCS, and the presence of anoxic brain injury on standard diffusion MRI. The goal is to determine if these MRI measures add prognostic information beyond conventional imaging. Participants undergo MRI during the acute phase and are followed for six months to assess outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* survive of an in or out of hospital cardiac arrest

Exclusion Criteria:

* Drug overdose
* Opinion of medical team patient unlikely to survive more than 24 hours (severe concurrent medical illness, dilated and unreactive pupils, etc..)
* Following verbal commands (MD or RN note) once TTM is complete and normothermia is achieved (Day 2 or 3; Day of admission is Hospital Day 0). If no TTM is administered, this can be assessed on Hospital Day 2.
* Following verbal commands (study team assessment) at time of MRI
* Family planning to WLST at time of enrollment
* Non English speaker (okay if English not primary language, as long as they can understand it)
* Permanent Contraindication to MRI (some kind of implanted metal)
* Pregnant

Where it's running

• Brigham and Women's Hospital
  Brookline, Massachusetts, United States Recruiting
• Brigham and Women's Hospital
  Boston, Massachusetts, United States Active not recruiting

Study contacts

• Study coordinator: Samuel B Snider, MD
• Email: ssnider@bwh.harvard.edu
• Phone: 857-307-2391

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.