Effects of mean arterial pressure on outcomes after out-of-hospital cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of maintaining different levels of mean arterial pressure (MAP) on patients who have experienced out-of-hospital cardiac arrest. The study aims to determine whether targeting a higher MAP of 90 mmHg, compared to the standard 65 mmHg, can improve neurological outcomes and overall survival rates. Patients will be monitored in the intensive care unit (ICU) after achieving return of spontaneous circulation (ROSC) and will be assessed for their neurological status and recovery. The trial seeks to clarify the optimal MAP threshold for post-cardiac arrest care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Admission to ICU following an out-of-hospital cardiac arrest with an initially shockable or non-shockable rhythm ;
* Sustained ROSC defined as 20 minutes with signs of circulation without the need for chest compressions;
* Under invasive mechanical ventilation for coma, defined as a Glasgow score ≤ 8/15;
* Consent from a relative or of a procedure for emergency inclusion.

Exclusion Criteria:

* Age \< 18 years ;
* In-hospital cardiac arrest (first cardiac arrest);
* Unwitnessed CA with initial rhythm of asystole
* Delay between ROSC and attempting randomisation \> 6 hours ;
* Cardiac arrest in a context of multiple trauma ;
* Cardiac arrest in a context of hemorrhagic shock or severe hemorrhage necessitating hemostasis (surgery or radiological or endoscopic hemostasis) ;
* Cardiac arrest secondary to an acute brain disease (ischemic or hemorrhagic stroke, subarachnoid hemorrhage, severe traumatic brain injury) ;
* Refractory shock :

Defined as a MAP \< 65 mmHg for more than one hour on norepinephrine or epinephrine at a dose \> 1 µg/kg/min despite adequate fluid resuscitation ;

* Extracorporeal circulatory support prior to inclusion;
* Known allergy to norepinephrine or to any of its excipients;
* Decision to limit care before inclusion ;
* Modified Rankin score of 4 or 5 before cardiac arrest ;
* Inclusion in another interventional study in which the principal endpoint is neurological prognosis ;
* Pregnancy or breast feeding ;
* Adult patient deprived of freedom or under legal protection (patients under guardianship or curatorship) (article L1121-6 of the French Health Code) ;
* Non-French speaking;
* Patient already included in this trial ;
* Absence of social security cover.

Where it's running

• CHU Brest - Hôpital de La Cavale Blanche
  Brest, France Recruiting
• CH Brive
  Brive-la-Gaillarde, France Recruiting
• CHU Caen
  Caen, France Recruiting
• CH Cholet
  Cholet, France Recruiting
• CH Dieppe
  Dieppe, France Recruiting
• CHU Dijon - Hôpital F. Mitterrand
  Dijon, France Recruiting

Study contacts

• Study coordinator: Christelle JADEAU
• Email: cjadeau@ch-lemans.fr
• Phone: +33244710781

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.