Cooling time and recovery after pediatric cardiac arrest
2/2 Pediatric Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
This project tests whether keeping children colder for longer after out-of-hospital cardiac arrest helps their brains recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11173870 on NIH RePORTER |
What this research studies
If a child is resuscitated after out-of-hospital cardiac arrest, doctors will use therapeutic cooling and compare different cooling durations to see which leads to better recovery. The team will track survival and brain function using standard measures like the Vineland Adaptive Behavior Scales–Third Edition. Researchers will build a duration-response curve to identify an optimal 'dose' of cooling across a wide pediatric age range. The work is carried out at participating hospitals with clinical care and follow-up visits to measure outcomes.
Who could benefit from this research
Good fit: Children who are successfully resuscitated after out-of-hospital cardiac arrest and receive targeted temperature management at participating hospitals are ideal candidates.
Not a fit: Children who are not resuscitated, who have unsurvivable brain injury, or for whom therapeutic cooling is not medically appropriate are unlikely to benefit from this effort.
Why it matters
Potential benefit: If successful, this work could identify the best cooling time to improve survival and neurological recovery in children after cardiac arrest.
How similar studies have performed: Targeted temperature management has been used in adults with mixed results and pediatric evidence is limited, so this builds on known approaches but addresses the unanswered question of optimal duration.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Yeatts, Sharon Dziuba — Medical University of South Carolina
- Study coordinator: Yeatts, Sharon Dziuba
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.