Goal-directed neuroprotection bundle for adults after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

LAPTOPS is a pragmatic interventional trial that randomizes adult patients who remain unconscious after return of spontaneous circulation following in- or out-of-hospital cardiac arrest to either a goal-directed neuroprotection care bundle or usual care. The bundle targets body temperature, PaCO2, PaO2, patient positioning, blood glucose, sodium, blood pressure and lactate levels during the acute post-arrest phase. The trial enrolls adults aged 18–79 who achieve ROSC within prespecified time windows and whose surrogates provide consent. Clinical and neurological recovery outcomes are compared between groups to determine whether a standardized bundle improves recovery in routine care settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years and \< 80 years
* Patients of in-hospital or out-of-hospital cardiac arrest who have returned -spontaneous circulation (ROSC) after cardiopulmonary resuscitation and do not require CPR for more than 20 minutes;
* Patients who are unconscious after ROSC, defined as FOUR motor response score \< 4 points or GSC ≤ 8 points;
* Family members or legal representatives signed informed consent.

Exclusion Criteria:

* Unwitnessed cardiac arrest, estimated time from cardiac arrest to start of CPR \> 30 minutes;
* Time from cardiac arrest to ROSC \> 60 minutes;
* Patients who woke up immediately after ROSC by CPR;
* End-stage diseases;
* Cardiac arrest considered to be caused by neurological diseases;
* The patient was in a vegetative state before cardiac arrest;
* The interval from the onset of cardiac arrest to enrollment is \>72 hours .

Where it's running

• Xiangya hospital，Central South University
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Lina Zhang
• Email: zln7095@163.com
• Phone: 86+15874875763

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.