Sedation and brain recovery after cardiac arrest
Role of Sedation in the Post-Cardiac Arrest Neurological Recovery
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11284021
This project looks at whether different sedation approaches help adults recover brain function after a cardiac arrest.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11284021 on ClinicalTrials.gov |
What this research studies
If I were a patient who regained circulation after a cardiac arrest but remained unconscious, doctors would continuously monitor my brain with quantitative EEG and record the sedative drugs and doses I receive. The team will compare how sedation depth and specific agents (for example, propofol-related slow-wave EEG patterns) relate to cerebral blood flow, metabolism, and early EEG markers. They will link those physiologic and EEG findings to clinical outcomes such as awakening, neurologic status, and survival to hospital discharge. The work is done at bedside in the ICU with careful clinical data and monitoring to determine whether sedation can help or harm brain recovery.
Who could benefit from this research
Good fit: Adults (21 years and older) who are comatose after return of spontaneous circulation following cardiac arrest and are receiving ICU care and sedation would be ideal candidates.
Not a fit: Children, people without cardiac arrest-related brain injury, or patients who are not sedated would not be expected to benefit or be eligible.
Why it matters
Potential benefit: If successful, this work could help clinicians choose sedation approaches that improve brain recovery and survival after cardiac arrest.
How similar studies have performed: Prior reports have linked sedative-induced slow-wave EEG patterns (for example with propofol) to better outcomes, but the direct role of sedation after cardiac arrest is still unproven.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ICHINOSE, FUMITO — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: ICHINOSE, FUMITO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury