How oxygen levels relate to when circulation stops during controlled (Maastricht III) organ donation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure blood oxygen levels in donors during the Maastricht III controlled withdrawal of life-sustaining therapy and at the moment of cardiocirculatory arrest. Serial blood samples will be collected from consenting adult donors and linked to precise timing of circulation loss, with limited clinical data recorded. De-identified data will also be collected from adult recipients who receive organs from those donors. The work is carried out at several French university hospitals under the existing legal framework for Maastricht III donation.

Why it matters

Who can join: the full rules

FOR THE DONORS :

Inclusion Criteria :

* Patient over 18 years of age
* Organ donation procedure initiated in accordance with the legislation and procedures in force in France for the Maastricht III category
* No opposition formulated by the relative to the patient's participation in the study

Exclusion Criteria :

* Patient registered on the national register of refusals or living refusal of donation
* Pregnant or breast-feeding women
* Patients under guardianship, curatorship or legal protection
* Medical contraindication to organ donation according to the recommendations of the Agence de Biomédecine currently in force in France

FOR THE RECEIVER

Inclusion Criteria :

* No opposition to the collection of data concerning him/her
* Patient over 18 at pre-transplant consultation
* Patient who has received an organ from a donor participating in the HEPHAISTOS protocol

Exclusion Criteria :

\- Patients under guardianship, curatorship or legal protection

Where it's running

• CHU ANGERS - Réanimation médicale
  Angers, France Recruiting
• CH ANNECY GENEVOIS - Réanimation médicale - Coordination Prélèvements multi-organes
  Annecy, France Recruiting
• CH AVIGNON - CH Henri Duffaut - Réanimation polyvalente
  Avignon, France Recruiting
• CHD Vendée - Les Oudairies - Médecine Intensive Réanimation
  La Roche-sur-Yon, France Recruiting
• CHU LILLE - Hôpital Roger Salengro - Médecine Intensive Réanimation
  Lille, France Recruiting
• CHU de Nantes - Hôpital Laennec
  Nantes, France Recruiting

Study contacts

• Study coordinator: Jean Baptiste LASCARROU
• Email: Jeanbaptiste.lascarrou@chu-nantes.fr
• Phone: 02 40 08 73 76

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Heartsight helps caregivers of kids after cardiac arrest manage uncertainty and fear

  This pilot trial tests if the Heartsight information program is acceptable and helpful for caregivers of children who recently had a cardiac arrest.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT07707037

• Brain blood flow and brain regulation in critically ill kids

  This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07613918

• Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients

  This trial will test whether adding a balloon occlusion of the descending aorta (REBOA) to standard ACLS helps people having an in-hospital cardiac arrest regain and keep a pulse.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07434726

• Digital serious game to improve critical care nurses' targeted temperature management skills and situational awareness.

  We will test whether adding a digital serious game to regular lectures helps adult ICU nurses learn targeted temperature management and improve situational awareness.

  Recruiting National Taiwan University Hospital · Taipei, Taipei · NCT07239206

• Plasma proteins, metabolites, and platelet changes in extracorporeal CPR for cardiac arrest patients

  This project will test whether patterns in blood proteins, small molecules, and platelet shape changes can help identify which adults with cardiac arrest might benefit from extracorporeal CPR.

  Recruiting Central China Fuwai Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07113769

• Targeted Temperature Management at 33°C for in-hospital cardiac arrest

  This trial tests whether cooling patients who remain unconscious after a resuscitated in-hospital cardiac arrest to 33°C improves survival with good brain function compared to keeping a normal, controlled temperature.

  Recruiting at 31 sites Nantes University Hospital · Ghent, Belgium and 30 other locations · NCT07086703

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.