Infusion of sodium lactate after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase II clinical trial aims to evaluate the safety and efficacy of hypertonic sodium lactate (HSL) infusion in patients who have been resuscitated from cardiac arrest. The study will involve comatose patients who will be randomized to receive either HSL infusion or standard care for 24 hours. The primary outcome will be the measurement of serum biomarkers related to brain damage, specifically NSE, to assess the potential reduction in organ damage. The trial seeks to provide foundational data for future larger studies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years old
* Sustained (\> 20 minutes) return of spontaneous circulation (ROSC)
* Comatose (GCS \< 9)
* Time to ROSC \> 15'

Exclusion Criteria:

* Protected categories (Pregnant women)
* Anticipated withdrawal of support within 24 hours
* Traumatic cause of cardiac arrest
* Body weight at admission \> 120Kg

Where it's running

• Erasme Hospital, Brussels University Hospital (HUB)
  Brussels, Belgium, Belgium Recruiting

Study contacts

• Principal investigator: Filippo Annoni, MD — Erasme University Hospital
• Study coordinator: Filippo Annoni, MD
• Email: filippo.annoni@erasme.ulb.ac.be
• Phone: 0483141483

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.