Pediatric cooling duration to improve brain recovery after out-of-hospital cardiac arrest
Official title: 1/2 Pediatric Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
Funded at University of Michigan at Ann Arbor · NIH-11421507 · Data updated 2026-11-12
This study tests the best length of cooling after cardiac arrest in children to help more kids recover with better brain function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 15, 2021 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $4,203,825 |
| NIH project number | 5UH3HL159134-06 |
| Project ID | NIH-11421507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children who have survived out-of-hospital cardiac arrest and are treated with cooling after resuscitation.
✕Less likely to help
Children who do not receive cooling or who have conditions making cooling unsuitable may not benefit.
What this research studies
After a child suffers an out-of-hospital cardiac arrest, protecting the brain is crucial. This UH3 grant will compare different durations of targeted temperature management to see which helps survivors recover their thinking and daily skills better. Researchers will monitor outcomes using standardized pediatric and neurodevelopmental assessments and track safety and feasibility of cooling protocols. The goal is to establish evidence on the optimal cooling time to improve survival with good neurologic function in a wide group of pediatric OHCA survivors.
Why it matters
Potential benefit: If successful, the approach could become a clearer standard for saving brain function after pediatric cardiac arrest.
How similar studies have gone: Previous research suggests cooling duration may influence brain outcomes, but optimal duration in children remains uncertain and this study aims to clarify it.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Moler, Frank W — University of Michigan at Ann Arbor
- Study coordinator: Moler, Frank W
Related research
Other NIH-funded projects on the same topics.
-
Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.