Plasma proteins, metabolites, and platelet changes in extracorporeal CPR for cardiac arrest patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study collecting plasma proteomic and metabolomic data plus detailed platelet ultrastructure from adults with refractory cardiac arrest treated with extracorporeal cardiopulmonary resuscitation (ECPR). Samples and platelet imaging will be obtained before and after ECPR to look for reproducible molecular and morphological markers. The goal is to find markers that predict which patients with reversible causes of arrest are most likely to benefit from ECPR. The work is being conducted at Central China Fuwai Hospital with regional hospital collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18 and 70 years old (the age limit can be relaxed if the patient has good organ function and a good neurological prognosis after evaluation).
2. The cardiac arrest is witnessed, and bystanders perform traditional cardiopulmonary resuscitation (CPR), and the time interval from the occurrence of cardiac arrest to the start of traditional CPR is no more than 5 minutes.
3. The causes of cardiac arrest are reversible, such as cardiogenic, pulmonary embolism, severe hypothermia, drug poisoning, trauma, acute respiratory distress syndrome, etc.
4. After 20 minutes of traditional CPR, there is no restoration of spontaneous circulation or hemodynamic instability, or the restoration of spontaneous circulation occurs, but the spontaneous heart rhythm cannot be maintained.
5. The informed consent has been signed.

Exclusion Criteria:

1. Infectious diseases, such as hepatitis B, hepatitis C, AIDS, syphilis, etc.
2. Hematological diseases, such as hematological malignancies, aplastic anemia, idiopathic thrombocytopenic purpura (ITP), etc.
3. Malignant tumors in other systems except the hematological system.
4. Patients who have received massive plasma or platelet transfusions during hospitalization or recently.

Where it's running

• Fuwai Central China Cardiovascular Hospital
  Zhengzhou, Henan, China Recruiting

Study contacts

• Study coordinator: Jianchao Li
• Email: 381226651@qq.com
• Phone: +86 185 3998 9191

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.