Target-directed management of brain oxygenation after ECPR

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study looks at patients who have undergone extracorporeal membrane oxygenation for cardiac arrest. It uses continuous cerebral oxygenation monitoring to categorize rSO2 readings and compare standard ECPR monitoring with a blinded monitoring approach. The goal is to see if targeted brain oxygenation management can influence neurological outcomes in patients with refractory arrests. The protocol emphasizes multimodal neuromonitoring and aims to clarify the timing and nature of acute brain injury during ECMO support. Results will inform best practices for protecting brain perfusion and oxygenation during ECPR.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. 18-75 years old
2. Witnessed in-hospital or out-of-hospital cardiac arrest
3. Patients who did not achieve return of spontaneous circulation (ROSC) after 15 minutes of conventional cardiopulmonary resuscitation (CPR), or whose ROSC cannot be maintained, and who received ECPR
4. Time from cardiac arrest to initiation of CPR \< 10 minutes
5. The cause of cardiac arrest is expected to be reversible (e.g., hypothermia, acute myocardial infarction/myocardial ischemia, malignant arrhythmia, pulmonary embolism, electrolyte abnormalities, hypoxia, anaphylactic shock, hemorrhage/hypovolemia, drug poisoning, electric shock, etc.)

Exclusion criteria:

1. Aortic dissection
2. Participants with active gastrointestinal bleeding or other conditions with contraindications to anticoagulation
3. Pregnancy
4. Severe trauma
5. Cerebral Performance Category (CPC) score \> 2 before cardiac arrest, or acute cerebrovascular disease (e.g., suspected or confirmed acute stroke, subarachnoid hemorrhage, etc.)
6. Terminal diseases, such as malignant tumors, end-stage liver and kidney diseases, severe heart failure (NYHA class III or IV), severe COPD (GOLD class III or IV), etc.
7. Transfer time from cardiac arrest to extracorporeal membrane oxygenation (ECMO) \> 90 minutes
8. Previous history of bilateral femoral artery bypass grafting or artificial vascular replacement, unsuitable for ECMO catheterization

Where it's running

• Qilu hospital
  Jinan, Shandong, China Recruiting
• Qilu Hospital
  Jinan, Shandong, China Not yet recruiting

Study contacts

• Study coordinator: Xianfei Ji, MD. PhD
• Email: qlyyjxf@163.com
• Phone: 0086-531-82165072

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Heartsight helps caregivers of kids after cardiac arrest manage uncertainty and fear

  This pilot trial tests if the Heartsight information program is acceptable and helpful for caregivers of children who recently had a cardiac arrest.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT07707037

• Brain blood flow and brain regulation in critically ill kids

  This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07613918

• Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients

  This trial will test whether adding a balloon occlusion of the descending aorta (REBOA) to standard ACLS helps people having an in-hospital cardiac arrest regain and keep a pulse.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07434726

• Digital serious game to improve critical care nurses' targeted temperature management skills and situational awareness.

  We will test whether adding a digital serious game to regular lectures helps adult ICU nurses learn targeted temperature management and improve situational awareness.

  Recruiting National Taiwan University Hospital · Taipei, Taipei · NCT07239206

• Plasma proteins, metabolites, and platelet changes in extracorporeal CPR for cardiac arrest patients

  This project will test whether patterns in blood proteins, small molecules, and platelet shape changes can help identify which adults with cardiac arrest might benefit from extracorporeal CPR.

  Recruiting Central China Fuwai Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07113769

• Targeted Temperature Management at 33°C for in-hospital cardiac arrest

  This trial tests whether cooling patients who remain unconscious after a resuscitated in-hospital cardiac arrest to 33°C improves survival with good brain function compared to keeping a normal, controlled temperature.

  Recruiting at 31 sites Nantes University Hospital · Ghent, Belgium and 30 other locations · NCT07086703

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.