Cardiopulmonary resuscitation with balloon occlusion of the descending aorta for hospitalized patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults who have an in-hospital cardiac arrest outside the operating room, ICU, or cath lab and who meet inclusion criteria will be randomized during active resuscitation to receive standard advanced cardiac life support (ACLS) alone or ACLS plus placement of a REBOA catheter to occlude the descending thoracic aorta. A research team deploys simultaneously with the clinical resuscitation team, and femoral artery access must be obtained to allow randomization. The primary focus is frequency of sustained return of spontaneous circulation (ROSC); secondary care, imaging contrast risks, and exclusion criteria such as asystole, pregnancy, known DNR, traumatic arrest, or prohibitive aortic pathology are pre-specified. The intervention is performed in-hospital with immediate monitoring and standard post-ROSC care.

Why it matters

Who can join: the full rules

Inclusion criteria:

* patients suffering from in hospital cardiac arrest (IHCA), including patients with out of hospital cardiac arrest (OHCA) and return of spontaneous circulation (ROSC), transported to the emergency department, where they suffer a second arrest (IHCA)
* successful placement of a femoral artery introducer sheath
* any electrical cardiac activity seen in the initial rhythm analysis
* ongoing effort of resuscitation as determined by study-independent resuscitation lead

Exclusion criteria:

* IHCA in the operating room, on intensive care unit or in the cardiac catheter laboratory
* hospital visitors suffering from cardiac arrest
* asystole seen in the initial rhythm analysis
* (presumed) age under 18 years
* known "do not resuscitate"-order
* known or obvious pregnancy
* traumatic cardiac arrest
* known aortic pathologies that render cannulation impossible
* known allergies to radiographic contrast agents

Where it's running

• Inselspital University Hospital Bern
  Bern, Switzerland Recruiting

Study contacts

• Principal investigator: Tanja Birrenbach, MD, MME — Inselspital University Hospital Bern
• Study coordinator: Tanja Birrenbach, MD, MME
• Email: tanja.birrenbach@insel.ch
• Phone: +41 31 632 57 01

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.