Examining energy use in cardiac arrest patients undergoing temperature management

Resting Energy Expenditure and Substrate Consumption in Cardiac Arrest Patients Under Target Temperature Management

This study is testing how much energy cardiac arrest patients need while they are being cooled down in the ICU to see if different temperatures affect their recovery.

Quick facts

• Study type: Observational
• Enrollment: 40 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Capital Medical University (Academic / other)
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT06575101 on ClinicalTrials.gov

What this trial studies

This observational study aims to analyze resting energy expenditure and substrate consumption in cardiac arrest patients who are undergoing targeted temperature management (TTM) in an intensive care unit. A total of 40 patients will be enrolled after successful cardiopulmonary resuscitation and will be divided into two groups based on their core body temperature: one group at 33 °C and the other at 36 °C. Baseline data will be collected, and patients will receive parenteral nutrition after a fasting period to assess their energy expenditure at various time points during their treatment. The study seeks to provide insights into the metabolic needs of these patients during critical care.

Who should consider this trial

Good fit: Ideal candidates for this study are adults over 18 years old who have been successfully resuscitated from cardiac arrest and are unconscious upon admission to the ICU.

Not a fit: Patients with traumatic brain injuries, severe metabolic abnormalities, or those who do not show signs of resuscitation upon admission may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could help optimize nutritional support for cardiac arrest patients, potentially improving their recovery outcomes.

How similar studies have performed: While there is limited data on this specific approach, similar studies on targeted temperature management have shown promising results in improving outcomes for cardiac arrest patients.

Eligibility criteria

Inclusion Criteria:

* Be admitted to the emergency department of Beijing Chao-yang Hospital, Capital Medical University;
* Successfully resuscitated, and are unconscious after restoration of spontaneous circulation (ROSC);
* Be admitted to the intensive care unit (ICU) for advanced life support such as endotracheal intubation after restoration of spontaneous circulation (ROSC);
* Accepted target temperature management (TTM) therapy after restoration of spontaneous circulation (ROSC);

Exclusion Criteria:

* Age \> 18 years old；
* Incomplete clinical data and loss of follow-up;
* Traumatic brain injury or cerebrovascular accident revealed by computed tomography (CT)；
* Severe metabolic abnormalities are known: cachexia, thyroid dysfunction, and cancer；
* Indirect calorimetry measurement is not possible such as sustained oxygen concentration \> 70%；
* There were no signs of resuscitation at the time of admission；

Where this trial is running

Beijing, Beijing Municipality

• Beijing chao-yang Hospital, Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)

Study contacts

• Study coordinator: Ziren Tang, MD

Conditions Targeted Temperature Management; Cardiac Arrest; Resting Energy Expenditure; Nutrition