Using heart rate variability to predict brain injury after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the role of heart rate variability (HRV) as a potential early predictor of noxic brain injury in patients who have experienced cardiac arrest. Patients admitted to the intensive care unit (ICU) after resuscitation will undergo 24-hour Holter monitoring to assess their HRV. The study seeks to improve prognostication in comatose patients following restoration of spontaneous circulation (ROSC) by evaluating HRV alongside existing clinical and paraclinical tests. The goal is to enhance the accuracy of predicting neurological outcomes in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Admitted in intensive care unit (ICU) after resuscitation from cardiac arrest (in-hospital or out-of-hospital)
* Coma (Glasgow score \< 8) after ROSC, requiring sedation and targeted temperature management for at least 24h

Exclusion Criteria:

* Dying patient (Limitation of life support techniques at admission to the ICU)
* Non-Sinus Rhythm
* Pregnant or breastfeeding women
* Patient under protection of the adults (guardianship, curators or safeguard of justice)
* Opposition by the trusted person or by the patient once he/she wakes up

Where it's running

• Brest University Hospital
  Brest, Brittany Region, France Recruiting
• Nantes University Hospital
  Nantes, Pays de la Loire Region, France Recruiting
• Marseille University Hospital
  Marseille, Provence-Alpes-Côte d'Azur Region, France Recruiting
• Ambroise Paré - Hartmann Private Hospital Group
  Neuilly-sur-Seine, Île-de-France Region, France Recruiting
• Cochin Hospital
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Study coordinator: Guillaume GERI, MD, PhD
• Email: guillaume.geri@clinique-a-pare.fr
• Phone: 0146415079

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.