Investigating brain-heart interactions after cardiac arrest
Brain Heart InterActioNs in Cardiac Arrest. Ancillary Study of the HEAVENwARd Trial
This study is trying to understand how the brain and heart work together in patients who have survived cardiac arrest to see if it can help predict their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | CMC Ambroise Paré Academic / other |
| Locations | 5 sites (Brest, Brittany Region and 4 other locations) |
| Trial ID | NCT06327334 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the brain-heart interactions in patients who have experienced cardiac arrest and have been resuscitated. It is an ancillary study to the HEAVENwARd trial, focusing on identifying new prognostic markers that can predict outcomes for patients with hypoxic-ischemic brain injury. The study will include patients admitted to intensive care units who have undergone EEG monitoring as part of their routine care. By analyzing these interactions, the researchers hope to improve prognostic evaluations for patients recovering from cardiac arrest.
Who should consider this trial
Good fit: Ideal candidates are patients admitted to the ICU after resuscitation from cardiac arrest who are in a coma and require sedation and targeted temperature management.
Not a fit: Patients who are dying or have limitations on life support before EEG monitoring may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prognostic tools for predicting outcomes in cardiac arrest survivors.
How similar studies have performed: Other studies have shown promise in understanding brain-heart interactions, but this specific approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Admitted in intensive care unit (ICU) after resuscitation from cardiac arrest (in-hospital or out-of-hospital) * Coma (Glasgow score \< 8) after ROSC, requiring sedation and targeted temperature management for at least 24h * EEG with ECG lead performed in routine care Exclusion Criteria: * Dying patient (Limitation of life support techniques at admission to the ICU) * Limitation of life sustaining treatment before EEG * Non-Sinus Rhythm * Pregnant or breastfeeding women * Patient under protection of the adults (guardianship, curators or safeguard of justice) * Opposition by the trusted person or by the patient
Where this trial is running
Brest, Brittany Region and 4 other locations
- Brest University Hospital — Brest, Brittany Region, France (Recruiting)
- Nantes University Hospital — Nantes, Pays de la Loire Region, France (Recruiting)
- Marseille University Hospital — Marseille, Provence-Alpes-Côte d'Azur Region, France (Recruiting)
- Ambroise Paré - Hartmann Private Hospital Group — Neuilly-sur-Seine, Île-de-France Region, France (Recruiting)
- Cochin Hospital — Paris, Île-de-France Region, France (Recruiting)
Study contacts
- Study coordinator: Sarah BENGHANEM, MD
- Email: sarah.benghanem@aphp.fr
- Phone: 01 58 41 25 33
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.