Investigating brain-heart interactions after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the brain-heart interactions in patients who have experienced cardiac arrest and have been resuscitated. It is an ancillary study to the HEAVENwARd trial, focusing on identifying new prognostic markers that can predict outcomes for patients with hypoxic-ischemic brain injury. The study will include patients admitted to intensive care units who have undergone EEG monitoring as part of their routine care. By analyzing these interactions, the researchers hope to improve prognostic evaluations for patients recovering from cardiac arrest.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Admitted in intensive care unit (ICU) after resuscitation from cardiac arrest (in-hospital or out-of-hospital)
* Coma (Glasgow score \< 8) after ROSC, requiring sedation and targeted temperature management for at least 24h
* EEG with ECG lead performed in routine care

Exclusion Criteria:

* Dying patient (Limitation of life support techniques at admission to the ICU)
* Limitation of life sustaining treatment before EEG
* Non-Sinus Rhythm
* Pregnant or breastfeeding women
* Patient under protection of the adults (guardianship, curators or safeguard of justice)
* Opposition by the trusted person or by the patient

Where it's running

• Brest University Hospital
  Brest, Brittany Region, France Recruiting
• Nantes University Hospital
  Nantes, Pays de la Loire Region, France Recruiting
• Marseille University Hospital
  Marseille, Provence-Alpes-Côte d'Azur Region, France Recruiting
• Ambroise Paré - Hartmann Private Hospital Group
  Neuilly-sur-Seine, Île-de-France Region, France Recruiting
• Cochin Hospital
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Study coordinator: Sarah BENGHANEM, MD
• Email: sarah.benghanem@aphp.fr
• Phone: 01 58 41 25 33

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Plasma proteins, metabolites, and platelet changes in extracorporeal CPR for cardiac arrest patients

  This project will test whether patterns in blood proteins, small molecules, and platelet shape changes can help identify which adults with cardiac arrest might benefit from extracorporeal CPR.

  Recruiting Central China Fuwai Hospital of Zhengzhou University · Zhengzhou, Henan · NCT07113769

• Targeted Temperature Management at 33°C for in-hospital cardiac arrest

  This trial tests whether cooling patients who remain unconscious after a resuscitated in-hospital cardiac arrest to 33°C improves survival with good brain function compared to keeping a normal, controlled temperature.

  Recruiting at 31 sites Nantes University Hospital · Ghent, Belgium and 30 other locations · NCT07086703

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.