Improving survival rates after cardiac arrest using new techniques

Head Up CPR and Aortic Occlusion to Improve Survival after Refractory Cardiac Arrest

NIH-funded research Resuscitation Innovations LLC · NIH-11250321

This study is looking at new ways to help people who have had a cardiac arrest and aren't responding to regular CPR, by trying a combination of techniques that could improve blood flow to the brain and vital organs, giving them a better chance of survival.

Quick facts

Grant typeSbir 1 grant
Study typeNIH-funded research
Funding institutionResuscitation Innovations LLC NIH-funded
Lab location1 site (Minneapolis, UNITED STATES)
Project IDNIH-11250321 on NIH RePORTER

What this research studies

This research investigates innovative methods to enhance survival rates for patients experiencing refractory cardiac arrest, a condition where traditional resuscitation efforts fail. The approach focuses on combining head-up CPR with aortic occlusion to improve blood flow to the brain and vital organs during cardiac arrest. By exploring these techniques, the research aims to provide a new treatment option for patients who currently have very low chances of survival. The study will involve patients who have experienced cardiac arrest and will assess the effectiveness of these methods in real-time emergency situations.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who experience cardiac arrest and are unresponsive to standard resuscitation methods.

Not a fit: Patients who are not experiencing cardiac arrest or those who have already received effective resuscitation will not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly increase survival rates and improve outcomes for patients suffering from refractory cardiac arrest.

How similar studies have performed: While some techniques like ECMO and double sequential defibrillation have shown limited success, this specific combination of head-up CPR and aortic occlusion is a novel approach that has not been extensively tested.

Where this research is happening

Minneapolis, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.