Improving survival rates after cardiac arrest using new techniques
Official title: Head Up CPR and Aortic Occlusion to Improve Survival after Refractory Cardiac Arrest
Funded at Resuscitation Innovations LLC · NIH-11250321 · Data updated 2026-11-12
This study is looking at new ways to help people who have had a cardiac arrest and aren't responding to regular CPR, by trying a combination of techniques that could improve blood flow to the brain and vital organs, giving them a better chance of survival.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Resuscitation Innovations LLC NIH-funded |
| Lab location | 1 site (Minneapolis, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | January 23, 2026 |
| Funding year | 2025 |
| Award (this year) | $396,977 |
| NIH project number | 6R43HL177950-02 |
| Project ID | NIH-11250321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who experience cardiac arrest and are unresponsive to standard resuscitation methods.
✕Less likely to help
Patients who are not experiencing cardiac arrest or those who have already received effective resuscitation will not benefit from this research.
What this research studies
This research investigates innovative methods to enhance survival rates for patients experiencing refractory cardiac arrest, a condition where traditional resuscitation efforts fail. The approach focuses on combining head-up CPR with aortic occlusion to improve blood flow to the brain and vital organs during cardiac arrest. By exploring these techniques, the research aims to provide a new treatment option for patients who currently have very low chances of survival. The study will involve patients who have experienced cardiac arrest and will assess the effectiveness of these methods in real-time emergency situations.
Why it matters
Potential benefit: If successful, this research could significantly increase survival rates and improve outcomes for patients suffering from refractory cardiac arrest.
How similar studies have gone: While some techniques like ECMO and double sequential defibrillation have shown limited success, this specific combination of head-up CPR and aortic occlusion is a novel approach that has not been extensively tested.
Where this research is happening
-
Resuscitation Innovations LLC
Minneapolis, United States Active
Researchers
- Principal investigator: Lurie, Keith — Resuscitation Innovations LLC
- Study coordinator: Lurie, Keith
Related research
Other NIH-funded projects on the same topics.
-
Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.